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TranscriptomicsExpression and ChIP-seq analysis LPS stimulated THP-1 cells
This SuperSeries is composed of the following subset Series: GSE32141: Expression analysis LPS stimulated THP-1 cells in four paired samples GSE32324: ChIP-seq analysis LPS stimulated THP-1 cells Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-03-07 | E-GEOD-32325 | biostudies-arrayexpress
TranscriptomicsChemokine expression in retinal pigment epithelial cells in response to co-culture with activated T Cells
Purpose: To investigate the effects of T cell-derived cytokines on gene and protein expression of chemokines in a human RPE cell line (ARPE-19). Methods: We used an in vitro co-culture system in which the RPE and CD3/28-activated T cells were separated by a membrane. Differential gene expression in...
ORGANISM(S): Homo sapiens 
2012-11-19 | E-GEOD-36331 | biostudies-arrayexpress
TranscriptomicsTissue Factor Pathway Inhibitor-2 is Induced by Fluid Shear Stress in Vascular Smooth Muscle
Tissue Factor Pathway Inhibitor-2 is Induced by Fluid Shear Stress in Vascular Smooth Muscle Cells and Affects Cell Proliferation and Survival Introduction: Vascular smooth muscle cells (SMCs) are exposed to fluid shear stress (FSS) after interventional procedures such as balloon-angioplasty. Wher...
ORGANISM(S): Rattus norvegicus 
2010-04-12 | E-GEOD-19909 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human reintal pigment epithelial cells and activated T-cells cultured alone or together
Background: Age-related macular degeneration (AMD) is caused by the degeneration of the macular photoreceptors. This is preceded by development of subretinal protein aggregates (drusen) and degeneration of the macular retinal pigment epithelium (RPE). The underlying pathogenesis remains unknown, but...
ORGANISM(S): Homo sapiens 
2009-10-23 | E-GEOD-17938 | biostudies-arrayexpress
TranscriptomicsBiobank of Karolinska Endarterectomy (BiKE)
A biobank collection of carotid plaque samples taken from patients undergoing endarterectomy operations. Samples from carotid plaques and peripheral blood mononuclear cells in a setup with clinical registry data collection. See PMID 22371308 for further details.
ORGANISM(S): Homo sapiens 
2012-03-27 | E-GEOD-21545 | biostudies-arrayexpress
TranscriptomicsExpression analysis LPS stimulated THP-1 cells in four paired samples
Macrophages play a critical role in innate immunity, and the expression of early response genes orchestrate much of the initial response of the immune system. Macrophages undergo extensive transcriptional reprogramming in response to inflammatory stimuli such as Lipopolysaccharide (LPS). To identif...
ORGANISM(S): Homo sapiens 
2012-03-07 | E-GEOD-32141 | biostudies-arrayexpress
GenomicsChIP-seq analysis LPS stimulated THP-1 cells
Macrophages play a critical role in innate immunity, and the expression of early response genes orchestrate much of the initial response of the immune system. Macrophages undergo extensive transcriptional reprogramming in response to inflammatory stimuli such as Lipopolysaccharide (LPS). To identif...
ORGANISM(S): Homo sapiens 
2012-03-07 | E-GEOD-32324 | biostudies-arrayexpress
TranscriptomicsGene expression and genotype in normal heart
Genome-wide association studies have identified a small region at chromosome 9p21.3 strongly associated with coronary heart disease risk. The region contains no protein-coding genes and the mechanism underlying its association with heart disease is unknown. We investigated associations between rs133...
ORGANISM(S): Homo sapiens 
2012-07-03 | E-GEOD-22253 | biostudies-arrayexpress
TranscriptomicsEffects of exendin-4 in Brunner's glands of male GLP-1R-/- and wild-type control mice
To gain insight into the biological functions of the highly expressed GLP-1R in Brunner’s glands, transcriptome analyses were conducted in male GLP-1R-/- and wild-type control mice. Analyses were performed 6 hours after a single s.c. dose of exendin-4 (1.0mg/kg s.c.), following 18 hours of two d...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-80119 | biostudies-arrayexpress
TranscriptomicsAdvanced Study of Aortic Pathology (ASAP)
BACKGROUND: The vast majority of thoracic aortic aneurysms (TAAs) are observed either together with a bicuspid aortic valve (BAV), a common congenital disorder, or in idiopathic cases such as patients with a normal tricuspid aortic valve (TAV). The main objective of our study was to identify shared ...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-26155 | biostudies-arrayexpress
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