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MetabolomicsAndrogens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome-GC-MS analysis of follicular fluid
Polycystic ovary syndrome (PCOS) is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression of PCOS. However, the underlying mechanism remains unclear. In this study, we conducted targeted me...
2025-04-14 | MTBLS12371 | MetaboLights
MetabolomicsResolvin E1 in follicular fluid acts as a potential biomarker and improves oocyte developmental competence by optimizing cumulus cells

The metabolic profile of follicular fluid (FF) has been investigated to look for biomarkers for oocyte quality. Resolvin E1 (RvE1), a potent pro-resolving mediator, was reported to have protective action in cell function. The study aimed to examine the predictive value of RvE1 for oocyte quality ...

2020-03-26 | MTBLS1488 | MetaboLights
MetabolomicsUHPLC-OE-MS metabolic profile of follicular fluid in patients with ovarian endometriosis: a pilot study of an endometriosis cohort

BACKGROUND: Endometriosis is a common benign gynaecological disorder. A number of studies have confirmed that the occurrence of disease in endometriosis patients is associated with metabolic changes in biological fluids and tissues. We set out to investigate the metabolic charact...

2024-02-20 | MTBLS8621 | MetaboLights
TranscriptomicsmiRNAs in follicular fluid
Our aim with this work is to identify and quantify the miRNA profile of the human follicular fluid using a miRNA microarray approach in young and advanced-aged women and in follicles with different oocyte quality. Data collected in this study would be utilized in a future as a marker to predict the...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-63737 | biostudies-arrayexpress
ProteomicsComparison of proteomic sample preparation and data analysis methods by means of human follicular fluids
In-depth proteome exploration of complex body fluids is a challenging task that requires optimal sample preparation and analysis in order to reach novel and meaningful insights. Analysis of follicular fluids is similarly difficult as that of blood serum due to the ubiquitous presence of several high...
ORGANISM(S): Homo sapiens (Human) 
2018-12-04 | PXD009061 | Pride
Proteomics Data analysis Follicular fluids Sample preparation 
ProteomicsPROTEOMIC AND FUNCTIONAL ANALYSIS OF ALPACA (VICUGNA PACOS) SPERM QUALITY FOLLOWING IN VITROCAPACITATION WITH FOLLICULAR AND OVIDUCTAL FLUIDS
Assisted reproductive technologies, such as in vitro fertilization, remain inefficient in camelids, largely due to gaps in understanding the molecular interactions that regulate sperm capacitation. Fertilization requires not only viable spermatozoa but also precise modulation of capacitation by the ...
ORGANISM(S): Vicugna pacos 
2025-10-27 | PXD068210 | Pride
Oviductal fluid Follicular fluid Sperm quality South amercan camelids Spermatozoa 
ProteomicsQuantitative mass spectrometric analysis to unravel glycoproteomic signature of follicular fluid in women with polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a complex endocrinopathy affecting reproductive aged women, whose etiology has not been fully understood yet. The follicular growth is arrested at preantral stage leading to cyst formation, consequently resulting in anovulatory infertility in these women. As folli...
ORGANISM(S): Homo sapiens (Human) 
2019-03-22 | PXD012731 | Pride
Follicular fluid quantitative glycoproteomics Mass spectrometry Ovarian pathophysiology Infertility 
ProteomicsProteomic analysis of follicular fluid of Patients with Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a common disorder encompassing reproductive, metabolic, and endocrine abnormalities, affecting 5 to 10% of women of reproductive age.To reveal the differences in proteomic profiles of follicular fluid between patients with and without PCOS and explore possible mec...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031996 | Pride
Proteomics Follicular fluid Tandem mass tag Polycystic ovary syndrome 
ProteomicsProteome of fluid from human small antral follicles reveals insights in folliculogenesis and oocyte maturation.
Human ovarian follicles develop a fluid-filled antrum when they reach a diameter of around 250 µm. The antrum contains follicular fluid (FF) composed of secretions from cells in the follicle and from circulation. The composition of FF undergoes massive changes in relation to follicular development. ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD013344 | Pride
Follicles Proteomics Human Folliculogenesis Follicular fluid 
GenomicsExtracellular vesicles microRNA cargo in porcine follicular fluids: the potential association with oocyte quality
Extracellular vesicles microRNA cargo in porcine follicular fluids: the potential association with oocyte quality
PRJNA750942 | ENA
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