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MetabolomicsFunctional Remodeling of the Gut Microbiome and Metabolome in Primary Idiopathic Male Infertility

Abstract

Background: Primary idiopathic male infertility (PIMI) is a complex condition with unclear biological mechanisms. Increasing evidence indicates that gut microbiome-derived functional and metabolic alterations can influence host physiological processes, yet microbiome-associated fun...

2026-04-07 | MTBLS13886 | MetaboLights
MetabolomicsMetabolomic profiling of follicular fluid from patients with infertility-related deep endometriosis.
Not available
ORGANISM(S): Homo sapiens 
ST000585 | MetabolomicsWorkbench
TranscriptomicsSystematic characterization of seminal plasma piRNAs as molecular biomarkers for male infertility
Although piwi-interacting RNAs (piRNAs) play pivotal roles in spermatogenesis, little is known about piRNAs in the seminal plasma of infertile males. In this study, we systematically investigated the profiles of seminal plasma piRNAs in infertile males to identify piRNAs that are altered during infe...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-78131 | biostudies-arrayexpress
TranscriptomicsArray-based DNA methylation profiling in male infertility reveals allele-specific DNA methylation in PIWIL1 and PIWIL2
Array-based DNA methylation profiling in peripheral blood leukocytes of 30 infertile men with impaired spermatogenesis as compared to 10 fertile men using the Illumina Infinium HumanMethylation 450k Bead Chip reveald 471 CpG sites (287 genes) to be differentially methylated between both groups. Thes...
ORGANISM(S): Homo sapiens 
2014-02-16 | E-GEOD-51245 | biostudies-arrayexpress
TranscriptomicsTesticular gene expression profiles in infertile patients with AZFc deletions of the Y chromosome
In the present study we carried out testicular gene expression profiling of patients with AZFc microdeletion, idiopathic infertility and normal spermatogenesis, in order to identify up- and downregulated genes in the different conditions, and to verify the presence of specific molecular pathways le...
ORGANISM(S): Homo sapiens 
2010-10-04 | E-GEOD-14310 | biostudies-arrayexpress
ClinicalA Follow-up Study of Women Evaluated and Treated for Infertility
To assess the relations of infertility causes and treatment to cancer risk, we will conduct a retrospective cohort study of approximately 12,000 women evaluated for infertility between 1965-1988. These women will be ascertained from several large infertility clinics and private practices in various ...
2030151 | ecrin-mdr-crc
ClinicalStudy of Information Received About Fertility and Infertility in Patients Who Have Finished Treatment for Cancer
RATIONALE: Learning about the amount of information on fertility and infertility by patients before they received treatment for cancer in a comprehensive cancer center may help doctors plan the best treatment. PURPOSE: This clinical trial is studying the amount of information on fertility and infert...
2102250 | ecrin-mdr-crc
ProteomicsMALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility
Spermatogenesis is a complex multi-step process involving intricate interactions between different cell types in the male testis. Disruption of these interactions results in infertility. Combination of shotgun tissue proteomics with MALDI imaging mass spectrometry is markedly potent in revealing top...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-07 | PXD022870 | Pride
Maldi imaging mass spectrometry Mouse Estrogen Arom+ Male infertility Testis 
ProteomicsTowards understanding male infertility after spinal cord injury through quantitative proteomics
The study of male infertility after spinal cord injury (SCI) has enhanced the understanding of seminal plasma (SP) as an important regulator of spermatozoa function. However, the most important factors leading to the diminished sperm motility and viability observed in semen of men with SCI remained ...
ORGANISM(S): Homo sapiens (Human) 
2016-02-01 | PXD002145 | Pride
Anejaculation Human seminal plasma Spinal cord injury Male infertility Quantitative proteomics Lc-ms/ms 
GenomicsExpression profiles of EMs-related infertility and tubal factor infertility granulosa cells revealed by RNA-seq
Expression profiles of EMs-related infertility and tubal factor infertility granulosa cells revealed by RNA-seq
PRJNA706566 | ENA
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