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ProteomicsLabel-free quantification of busulfan-treated testis
The busulfan-treated mouse model showed abnormal testis morphology and reduced sperm number and testis weight. Testicular and sperm damage was most severe at 30 days after busulfan treatment. The protein level of MGAT1 was increased in busulfan-treated mouse testis. The busulfan-treated mouse testes...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD035492 | Pride
Testis Busulfan Label-free quantification Spermatogenesis 
TranscriptomicsTranscription profiling of rat embryonic testis and ovaries of age E13, E14, or E16, and E13 testis to identify candidate genes in gonadal development
Embryonic day 13 (E13), E14, and E16 rat testes and ovaries were used for microarray analysis, as well as E13 testis organ cultures that undergo testis morphogenesis and develop seminiferous cords in vitro. A list of 109 genes resulted from a selective analysis for genes present in male gonadal deve...
ORGANISM(S): Rattus norvegicus 
2008-04-07 | E-GEOD-10558 | biostudies-arrayexpress
TranscriptomicsTranslational activation of developmental mRNAs during neonatal mouse testis development
The sequence of gene regulatory events that drive neonatal germ cell development in the mammalian testis is not yet clear. We assessed changes in mRNA utilization in the neonatal testis at 1 and 4 dpp, times when the testis contains quiescent gonocytes (1 dpp) and proliferating spermatogonia (4 dpp)...
ORGANISM(S): Mus musculus 
2013-07-27 | E-GEOD-49283 | biostudies-arrayexpress
ProteomicsCharacterization of Two Unknown Proteins in the Human Testis
This project aims at deciphering the human testis proteome and to discover and characterizedunknown proteins in order to better understand the male reproductive physiology.
ORGANISM(S): Homo sapiens (Human) 
2018-08-29 | PXD009598 | Pride
Testis Unknown proteins Dark proteins 
ProteomicsHuman testis off-line LC-MS/MS
In order to identify more MPs and get deeper proteomic data of testis. We applied high-pH reverse phase (RP) HPLC to fractionate complex samples.On the other hand, to enhance protein coverage, multi-protease strategies were used for 10% SDS-PAGE short separation samples.
ORGANISM(S): Homo sapiens (Human) 
2018-10-04 | PXD009737 | Pride
Off-line rp-hplc  multi-proteases  testis  missing proteins 
ProteomicsSilkworm testis LC-MS/MS - Proteomics analysis of adult testis from Bombyx mori
The development of the testis involves a large number of tissue-specific proteins, possibly because that sperms in it are the most divergent of all cell types. Although the proteome of the larval testis of Bombyx mori has been reported, no comprehensive data on adult testis proteome is available for...
ORGANISM(S): Bombyx mori (Silk moth) 
2014-07-28 | PXD000909 | Pride
Testis Silkworm Lc-ms/ms 
ProteomicsHuman_Testis_QE-HF - Deep Coverage Proteomics Identifies More Low-Abundance Missing Proteins in Human Testis Tissue with Q-Exactive HF Mass Spectrometer
The Chromosome-Centric Human Proteome Project (C-HPP) aims at finding existence evidence of missing proteins (MPs) at the early stage. Based on previous research, it has been proved that human testis tissue is suitable for further research of MPs because of its high gene expression level and high tr...
ORGANISM(S): Homo sapiens (Human) 
2016-09-30 | PXD004092 | Pride
Human Qe-hf Testis 
ProteomicsIntegrative proteomic and phosphoproteomic profiling of testis from Wip1-knockout mice: insights into mechanisms of reduced fertility
Spermatogenesis plays an important role in the mammalian testis, involving in the complex processes of mitosis, meiosis, and spermiogenesis. Spermatogenesis may also be disrupted in the absence of the immunological and ‘fence’ functions of the BTB, resulting in male subfertility or infertility. Mice...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-02 | PXD009220 | Pride
Fertility Proteomic Phosphoproteomic Knockout mice Testis Wip1 
TranscriptomicsTranscription profiling of rat embryonic day 16 testis RNA samples from F1, F2, F3 generation control groups vs F1, F2, F3 generation vinclozolin treated groups to examine transgenerational epigenetic programming of the embryonic testis
Embryonic exposure to the endocrine disruptor vinclozolin during gonadal sex determination appears to promote an epigenetic reprogramming of the male germ line that is associated with transgenerational adult-onset disease states. Transgenerational effects on the embryonic day 16 (E16) testis demonst...
ORGANISM(S): Rattus norvegicus 
2008-04-04 | E-GEOD-10919 | biostudies-arrayexpress
ProteomicsPhosphoproteome of mouse testis
Spermatogenesis is a complex sperm-generating process involving the mitosis of spermatogonia, meiosis of spermatocytes and spermiogenesis of spermatids. Elucidating the phosphorylation-based regulations should advance our understanding of the underlying molecular mechanisms. Here we present an integ...
ORGANISM(S): Mus musculus (Mouse) 
2014-10-10 | PXD000767 | Pride
Phosphorylation proteomics spermatogenesis testis 
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