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TranscriptomicsWIP1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation
WIP1 phosphatase is emerging as an important regulator of tumorigenesis, but no unifying mechanistic network has been proposed. Here we found that WIP1 plays a key role in the transcriptional regulation of heterochromatin-associated DNA sequences in germ-line and cancer cells. WIP1 was required for ...
ORGANISM(S): Mus musculus 
2013-10-19 | E-GEOD-46103 | biostudies-arrayexpress
ProteomicsMouse epididymis LC-MSMS - Male Fertility Potential Molecular Mechanisms Revealed by iTRAQ-Based Quantitative Proteomic Analysis of the Epididymis from Wip1-/- Mice
The wild-type p53-induced phosphatase 1 (WIP1) frustrated mice exhibited defects in reproductive organs. This study aimed to understand how Wip1 deficiency affects the spermatogenesis or maturation. We employed the Wip1-/- mouse model and conducted a gel-free iTRAQ LC-MS/MS based quantitative proteo...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-16 | PXD010125 | Pride
Lc-msms Mouse Sperm Itraq Epididymis 
TranscriptomicsExpression data from Wild type and Wip1 knockout Hematopoietic stem cell
Hematopoietic stem cell (HSC) aging underlies many age-related hematopoietic disorders. Accumulation of DNA damage is a hallmark of HSC aging. Wild-type p53-induced phosphatase 1 (Wip1) is a homeostatic regulator of DNA damage response. We used microarrays to detail the global programme of gene expr...
ORGANISM(S): Mus musculus 
2014-06-25 | E-GEOD-58754 | biostudies-arrayexpress
TranscriptomicsMurine liver tissues: WT and Wip1 KO mice after Partial Hepatectomy at 24h and 36 h.
Transcriptional profiling of mouse liver tissues comparing Wild type liver tissues with Wip1 KO mice liver tissues after Partial Hepatectomy at 24h and 36 h. WT vs. Wip1 KO tissues after Partial Hepatectomy at 24h and 36 h .
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-59023 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic fibroblasys from Wip1+/+ or -/- animals after gamma radiation
Assessment of p53 targets by gene expression array analysis in irradiated and nonirradiated Wip1+/+ and Wip1-/- MEFs. Experiment Overall Design: mRNA from each set of cells harvested four hours after IR (5 Gy) was Experiment Overall Design: used for gene expression microarray analysis of p53 target ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8704 | biostudies-arrayexpress
ProteomicsIntegrative proteomic and phosphoproteomic profiling of testis from Wip1-knockout mice: insights into mechanisms of reduced fertility
Spermatogenesis plays an important role in the mammalian testis, involving in the complex processes of mitosis, meiosis, and spermiogenesis. Spermatogenesis may also be disrupted in the absence of the immunological and ‘fence’ functions of the BTB, resulting in male subfertility or infertility. Mice...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-02 | PXD009220 | Pride
Fertility Proteomic Phosphoproteomic Knockout mice Testis Wip1 
ProteomicsProteome and phosphoproteome of Wip1-knockout mouse testis
Spermatogenesis plays an important role in the mammalian testis, involving in the complex processes of mitosis, meiosis, and spermiogenesis. Spermatogenesis may also be disrupted in the absence of the immunological and ‘fence’ functions of the BTB, resulting in male subfertility or infertility. Mice...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-01 | PXD008277 | Pride
Fertility Proteomic Phosphoproteomic Knockout mouse Wip1 Testis 
GenomicsTargeting WIP1 phosphatase promotes partial remission in experimental collapsing glomerulopathy
Targeting WIP1 phosphatase promotes partial remission in experimental collapsing glomerulopathy
PRJNA1051068 | ENA
TranscriptomicsGene expression in Wip1+/+ or -/- MEFs after gamma radiation
Assessment of p53 targets by gene expression array analysis in irradiated and nonirradiated Wip1+/+ and Wip1-/- MEFs. Keywords: response to gamma radiation
ORGANISM(S): Mus musculus 
2007-08-08 | GSE8704 | GEO
TranscriptomicsWip1 regulates adult neurogenesis and Wnt signaling during aging
The number of newly-formed neurons declines rapidly during aging. Here we describe an important mechanism that contributes to this decline via Wip1-dependent regulation of neuronal differentiation. We found that Wip1 is expressed in neural stem/progenitor cells (NPCs) of the mouse subventricular zon...
ORGANISM(S): Mus musculus 
2014-04-26 | GSE57105 | GEO
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