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MetabolomicsMetabolite annotation of rat epididymis with High-resolution imaging mass spectrometry
Infertility or subfertility is a widespread problem with approximately 25% of couples seeking medical help. For about half the cases it lies in the male partner. Male infertility is caused by problems that affect sperm production, maturation and/or transport. In this study the role played by the epi...
2018-05-17 | MTBLS58 | MetaboLights
ProteomicsA Comparative Study of Human Testes and Epididymis through the Proteomics and RNA-seq Methods
A Comparative Study of Human Testes and Epididymis through the Proteomics and RNA-seq Methods
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-13 | MSV000088554 | MassIVE
ProteomicsMouse epididymis LC-MSMS - Male Fertility Potential Molecular Mechanisms Revealed by iTRAQ-Based Quantitative Proteomic Analysis of the Epididymis from Wip1-/- Mice
The wild-type p53-induced phosphatase 1 (WIP1) frustrated mice exhibited defects in reproductive organs. This study aimed to understand how Wip1 deficiency affects the spermatogenesis or maturation. We employed the Wip1-/- mouse model and conducted a gel-free iTRAQ LC-MS/MS based quantitative proteo...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-16 | PXD010125 | Pride
Lc-msms Mouse Sperm Itraq Epididymis 
TranscriptomicsExpression profiles of cultured human epididymis cells reveal the functional diversity of caput, corpus and cauda regions.
Purpose: To compare the transcriptome profiles (RNA-seq) of cultured human epididymis cells and tissue from the caput, corpus and cauda regions of the human epididymis. Methods: Human epididymis tissue was obtained with Institutional Review Board approval from 3 patients (UC05, UC06, UC09, range: 22...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-72986 | biostudies-arrayexpress
GenomicsOpen chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function [Dnase-Seq]
The epithelium lining the epididymis in the male reproductive tract maintains a luminal environment that promotes sperm cell maturation. This process is dependent on the coordinated expression of many genes that encode proteins with a role in epithelial transport. We previously generated genome-wide...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-59782 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human epididymis
Analysis of the gene expression pattern in the caput, corpus and cauda epididymides of three donors of 26-50 years of age with no medical pathologies that could affect reproductive function. The data generated in this study demonstrate a region specific gene expression pattern along the human epidid...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7808 | biostudies-arrayexpress
TranscriptomicsOpen chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function [Rnase-Seq]
The epithelium lining the epididymis in the male reproductive tract maintains a luminal environment that promotes sperm cell maturation. This process is dependent on the coordinated expression of many genes that encode proteins with a role in epithelial transport. We previously generated genome-wide...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-59781 | biostudies-arrayexpress
TranscriptomicsOpen chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function [Agilent expression]
The epithelium lining the epididymis in the male reproductive tract maintains a luminal environment that promotes sperm cell maturation. This process is dependent on the coordinated expression of many genes that encode proteins with a role in epithelial transport. We previously generated genome-wide...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-60381 | biostudies-arrayexpress
TranscriptomicsAnalysis of the microRNA expression profile in the mouse epididymis detected by next generation sequencing
The functional maturation of mammalian spermatozoa is accomplished as the cells descend through the highly specialized microenvironment of the epididymis. This dynamic environment is, in turn, created by the combined secretory and absorptive activity of the surrounding epithelium and displays an ext...
ORGANISM(S): Mus musculus 
2015-07-29 | E-GEOD-70197 | biostudies-arrayexpress
ProteomicsHuman Epididymis Protein 4 Promotes Aberrant Epithelial-Fibroblast Crosstalk in Pulmonary Fibrosis
Invasive lung myofibroblasts are the main cause of tissue remodeling in idiopathic pulmonary fibrosis (IPF). A key mechanism contributing to this important feature is aberrant crosstalk between the abnormal/injured lung epithelium and pulmonary fibroblasts. Here, we demonstrated that lungs from pati...
ORGANISM(S): Homo Sapiens 
2024-12-17 | PXD058959 |
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