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TranscriptomicsOviduct-Embryo Interactions in Cattle: Two-Way Traffic or a One-Way Street? [Affymetrix]
The objective of this study was to examine the effect of the presence of a single or multiple embryo(s) on the transcriptome of the bovine oviduct. In Experiment 1, cyclic (non-bred, n = 6) and pregnant (artificially inseminated, n = 11) heifers were slaughtered on Day 3 after estrus, and the ampull...
ORGANISM(S): Bos taurus 
2015-11-04 | E-GEOD-74593 | biostudies-arrayexpress
TranscriptomicsEffects of pregnancy and progesterone supplementation on endometrial gene expression in cattle
An increase in circulating progesterone (P4) concentrations is associated with increased pregnancy success in beef and dairy cattle. Our objective was to ascertain differential effects of elevated P4 concentrations following conception on endometrial gene expression in beef heifers on Days 5, 7, 13 ...
ORGANISM(S): Bos taurus 
2011-10-17 | E-GEOD-33030 | biostudies-arrayexpress
ProteomicsEndometrium on-a-chip reveals insulin- and glucose-induced alterations in the transcriptome and proteomic secretome
The molecular interactions between the maternal environment and the developing embryo that are key for early pregnancy success are known to be influenced by factors such as maternal metabolic status. Our understanding of the mechanism(s) through which these individual nutritional stressors alter end...
ORGANISM(S): Bos taurus (Bovine) 
2021-03-22 | PXD024218 | Pride
Bovine Cattle Microfluidics Uterine luminal fluid Uterus Endometrium-on-a-chip 
ProteomicsPlacental mammal derived microRNAs alter pathways in the endometrial epithelia important for endometrial function
We tested the hypothesis that a panel of placental mammal-specific miRNAs and their targets play important to establish receptivity to implantation and their dysregulated expression may be a feature in women with early pregnancy loss. Relative expression levels of miR-340-5p, −542-3p, and −671-5p al...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD036109 | Pride
Proteomics Placental mammals Endometrium Microrna Human 
TranscriptomicsRNA-seq profiling of theca and granulosa tissue of dominant follicle at 3 stages of follicular development in cows and heifers.
Cellular mechanisms that contribute to low estradiol concentrations produced by the preovulatory ovarian follicle in cattle with a compromised metabolic status (such as lactatino) are largely unknown. To gain insight into the main metabolic mechanisms affecting preovulatory follicle function RNAseq ...
ORGANISM(S): Bos taurus 
2012-06-15 | E-GEOD-34317 | biostudies-arrayexpress
TranscriptomicsEvidence for an early endometrial response to pregnancy in cattle: both dependent upon and independent of interferon tau
The aims of this study were to 1) identify the earliest transcriptional response of the bovine endometrium to the presence of the conceptus (using RNAseq), 2) investigate if these genes are regulated by interferon tau (IFNT) in vivo, and 3) determine if they are predictive of the pregnancy status of...
ORGANISM(S): Bos taurus 
2014-04-01 | E-GEOD-56392 | biostudies-arrayexpress
ProteomicsThe embryo-derived protein PDI is highly conserved among placental mammals and alters the function of the endometrium in species with different implantation strategies.
Pregnancy establishment in mammals requires a complex sequence of events, including bi-lateral embryo-maternal communication, leading up to implantation. This is the time when most pregnancy loss occurs in mammals (including humans and food production species) and dysregulation in embryo-maternal co...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2026-01-06 | PXD067948 | Pride
Conditioned medium Uterine luminal fluid Bovine Microfluidics 
ProteomicsA bovine 3D endometrium-on-a-chip reveals the role of conceptus-derived factors CAPG and PDI in conceptus-endometrial communication
Early embryo loss affects all mammalian species, including humans and agriculturally important food-producing mammals such as cattle. The developing conceptus (embryo and extra-embryonic membranes) secretes factors which modify the endometrium and can be critical for early pregnancy processes such m...
ORGANISM(S): Bos taurus (Bovine) 
2025-05-19 | PXD059725 | Pride
Bovine Microfluidics Organ-on-a-chip Uterine luminal fluid Endometrium Secretome 
TranscriptomicsSexually dimorphic gene expression in bovine conceptuses at the initiation of implantation is not reflected in the changes in the endometrial transcriptome.
In cattle, maternal recognition of pregnancy occurs on Day 16 via secretion of interferon tau (IFNT) by the conceptus. The endometrium can distinguish between embryos with different developmental competencies. In eutherian mammals, X-chromosome inactivation (XCI) is required to ensure an equal trans...
ORGANISM(S): Bos taurus 
2016-03-01 | E-GEOD-75754 | biostudies-arrayexpress
TranscriptomicsSpatial Differences in Gene Expression in the Bovine Oviduct
The aim of this study was to compare the transcriptome of the different regions of the oviduct between pregnant and cyclic heifers. After synchronizing crossbred beef heifers, those in standing oestrus (=Day 0) were randomly assigned to cyclic (non bred, n=6), or pregnant (artificially inseminated, ...
ORGANISM(S): Bos taurus 
2016-03-01 | E-GEOD-75442 | biostudies-arrayexpress
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