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MetabolomicsCalenduloside E produced by Bifidobacterium animalis B960 increases glibenclamide efficacy and alleviates drug-induced adverse effects via the IRS1/PI3K/AKT signaling pathway in a type 2 diabetes model Calenduloside E produced by Bifidobacterium animalis B960 increases glibenclamide efficacy and alleviates drug-induced adverse effects via the IRS1/PI3K/AKT signaling pathway in cell, organ-on-a-chip, and mouse models of type 2 diabetes.

Glibenclamide (GLIB), a type 2 diabetes therapy, has long-term safety concerns. Probiotic–drug coadministration, an emerging adjunctive approach for metabolic diseases, improves therapeutic outcomes and side effects. Here, Bifidobacterium animalis B960 was selected from 71 probiotic strains by HP...

2025-07-08 | MTBLS12697 | MetaboLights
ProteomicsNormalization of Organ-on-a-Chip Samples for Mass Spectrometry Based Proteomics and Metabolomics via Dansylation-based Assay
Mass spectrometry based ‘omics pairs well with organ-on-a-chip-based investigations, which often have lim-ited cellular material for sampling. However, a common issue with these chip-based platforms is well-to-well or chip-to-chip variability in the proteome and metabolome due to factors such as pla...
ORGANISM(S): Homo sapiens (Human) 
2026-01-22 | PXD028927 | Pride
Liver Organ-on-a-chip Normalization 
ProteomicsA Novel Approach to Interrogating the Effects of Chemical Warfare Agent Exposure Using Organ-on-a-Chip Technology and Multiomic Analysis
Organ-on-a-chip platforms are utilized in global bioanalytical and toxicological studies as a way to reduce materials and increase throughput as compared to in vivo based experiments. These platforms bridge the infrastructure and regulatory gaps between in vivo animal work and human systems, with mo...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037722 | Pride
Multiomics Organ on a chip Liver Lcms Organophosphate 
ProteomicsMAPPING HEART FIBROSIS: INTEGRATIVE PHOSPHOPROTEOMIC PROFILING OF CLINICAL SAMPLES, ANIMAL AND ORGAN-ON-A-CHIP MODELS
Precision mass spectrometry, animal models and organ-on-a-chip (OOC) systems have emerged as promising experimental strategies to study the molecular mechanisms governing human biology and disease, including the molecular basis of cardiovascular disorders like fibrosis where access to patient sample...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-11-12 | PXD011107 | Pride
Human Mouse model Heart Hypertrophy Phosphoproteomic Organ-on-a-chip Fibrosis 
ProteomicsProteomic reveals reasons for acquired drug resistance in lung cancer derived brain metastasis based on a newly established multi-organ microfluidic chip model
Anti-tumor drugs can effectively shrink the lesions of primary lung cancer; however, it has limited therapeutic effect on patients with brain metastasis (BM). A BM preclinical model based on a multi-organ microfluidic chip has been established proficiently in our previous work. In this study, the BM...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021760 | Pride
Lung cancer  brain metastasis  microfluidic organ-on-a-chip  drug resistance  proteomic. 
UnknownState-of-the-Art Organ-on-Chip Models and Designs for Medical Applications: A Systematic Review.
Not available
S-EPMC12383757 | biostudies-literature
GenomicsModeling of lung-liver interaction during infection in a human fluidic organ-on-a-chip
Modeling of lung-liver interaction during infection in a human fluidic organ-on-a-chip
PRJNA1246642 | ENA
GenomicsMulti-organ immunity on a 3D-printed multi-tissue chip with tubing-free impeller pump
Multi-organ immunity on a 3D-printed multi-tissue chip with tubing-free impeller pump
PRJNA1114743 | ENA
ProteomicsEndothelial-neuronal coupling revealed in a decoupled neurovascular unit based Organ-on-Chip approach.
This data set is for the article: Endothelial-neuronal coupling revealed in a decoupled neurovascular unit based Organ-on-Chip approach.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-08-24 | MSV000081480 | MassIVE
GenomicsOrgan-on-a-chip reveals the synergistic effect of mregDC and Treg in non-small cell lung cancer
Organ-on-a-chip reveals the synergistic effect of mregDC and Treg in non-small cell lung cancer
PRJNA1315226 | ENA
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