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TranscriptomicsRNA-seq of HeLa cells to investigate regulation of replicative histone RNA metabolism by the histone chaperone ASF1
Histones are the protein components of the basic unit of chromatin, the core particle of the nucleosome. They play a central role in defining chromatin states associated with distinct cell fates and are classified into replicative and non-replicative/replacement histone variants. While the latter do...
ORGANISM(S): Homo sapiens 
2023-11-29 | E-MTAB-12501 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat kidney and liver from several different strains to determine the effects of hyperglycaemia and genetic background difference on gene expression
Effects of hyperglycaemia and genetic background differences on renal and hepatic gene expression
ORGANISM(S): Rattus norvegicus 
2009-06-03 | E-TABM-502 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hepatocytes from mice that are hyperglycaemic, obese and insulin resistant as a result of being fed a high fat diet - Illumina dataset
Effect of high fat diet feeding on gene expression
ORGANISM(S): Mus musculus 
2009-09-15 | E-TABM-548 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neurofibromatosis type 1
Genes involved in tumorigenesis associated with neurofibromatosis type 1.
ORGANISM(S): Homo sapiens 
2007-01-12 | E-TABM-69 | biostudies-arrayexpress
TranscriptomicsRNAi knock-down of MKL1 in human megakaryocytes derived from cord blood or cytapheresis
Characterize the genes regulated by MKL1/SRF complex in human megakaryocytes (MKs) derived from cord blood or cytapheresis : Using a knock down approach by small interference of MKL1 in MK progenitors, we observed a decrease in the percentage of cells with actin polymerization after adhesion on vari...
ORGANISM(S): Homo sapiens 
2009-09-14 | E-TABM-640 | biostudies-arrayexpress
TranscriptomicsRNA-seq of learning and control mice (Mus musculus) striatum across three temporal phases of learning
To understand the effects of learning on expression in mouse striatum, we combined an automated operant conditioning chamber (OCC) setup with an efficient RNA-sequencing protocol. We compared 450 striatal expression profiles from 75 mice, e.g., the data contains 6 samples per mouse. Biopsies were ta...
ORGANISM(S): Mus musculus 
2025-10-25 | E-MTAB-15694 | biostudies-arrayexpress
ProteomicsHighly multiplexed quantitative phosphosite assay for biology and preclinical studies
Reliable methods to quantify dynamic signaling changes across diverse pathways are needed to better understand the effects of disease and drug treatment in cells and tissues but are presently lacking. Here we present SigPath, a targeted mass spectrometry (MS) assay that measures 284 phosphosites in ...
ORGANISM(S): Homo Sapiens 
2021-10-08 | PXD026939 | panorama
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