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TranscriptomicsAvoiding chromosome pathology when replication forks collide
Chromosome duplication normally initiates via the assembly of replication fork complexes at defined origins. DNA synthesis by any one fork is thought to cease when it meets another travelling in the opposite direction, at which stage the replication machinery may simply dissociate before the nascent...
ORGANISM(S): Escherichia coli 
2013-07-22 | E-GEOD-41975 | biostudies-arrayexpress
TranscriptomicsT cell help controls the speed of the cell cycle in germinal center B cells.
The germinal center (GC) is a microanatomical compartment wherein high-affinity antibody-producing B cells are selectively expanded. B cells proliferate and mutate their antibody genes in the dark zone (DZ) of the GC and are then selected by T cells in the light zone (LZ) on the basis of affinity. H...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-71295 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of S. pombe co-overexpressing DNA synthesis initiation factors cdc18 (cdc6) and cdt1 to investigate gene copy number increases
During S-phase of the eukaryotic cell cycle, controls exist to ensure that replication origins fire only once and become inactivated after traverse of a replication fork. Failure of these controls results in local amplification of the genome which can lead to gene copy increases important for both ...
ORGANISM(S): Schizosaccharomyces pombe 
2010-08-13 | E-MTAB-139 | biostudies-arrayexpress
UnknownUnrepaired Base Excision Repair Intermediates in Template DNA Strands Trigger Replication Fork Collapse and PARP Inhibitor Sensitivity
Not available
S-SCDT-10_15252-EMBJ_2022113190 | biostudies-other
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