Fork stability - OmicsDI

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Simon J. Boulton FMedSci FRS Principal Group Leader The Francis Crick Institute Midland Road London, NW1 1AT, UK. (1)
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Department of Molecular Genetics, Erasmus University Medical Center, Erasmus MC Cancer Institute; Dr. Molewaterplein 40, 3015GD Rotterdam, The Netherlands (1)
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CRUK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Roosevelt Drive, Oxford, OX3 7DQ, UK (1)
Target Discovery Institute, University of Oxford, UK (1)
Mass Spectrometry/Proteomics Facility, Netherlands Cancer Institute, Amsterdam, Netherlands (1)
Dept. Oncology Pathology, Karolinska Institutet, and Scilifelab, Stockholm, Sweden (1)

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Top1 and Top2-mediated replication fork integrity

DNA topoisomerases solve topological problems during chromosome metabolism. We investigated where and when Top1 and Top2 are recruited on replicating chromosomes and how their inactivation affects fork integrity and DNA damage checkpoint activation. We show that, in the context of replicating chroma...

ORGANISM(S): Saccharomyces cerevisiae

2010-06-05 | E-GEOD-8305 | biostudies-arrayexpress

Dynamics of de novo heterochromatin assembly and disassembly at replication forks ensures fork stability

Chromatin is dynamically reorganized when DNA replication forks are challenged. However, the process of epigenetic reorganization and its implication for fork stability is poorly understood. Here, we discover a checkpoint regulated cascade of chromatin signaling that activates 5 the histone methyl...

ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse)

2023-05-12 | PXD041742 | Pride