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TranscriptomicsFormalin Fixation at Low Temperature Better Preserves Nucleic Acid Integrity
INTRODUCTION. Fixation with formalin, a widely adopted procedure to preserve tissue samples, leads to extensive degradation of nucleic acids and thereby compromises procedures like microarray-based gene expression profiling. We hypothesized that RNA fragmentation is caused by activation of RNAses du...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-27175 | biostudies-arrayexpress
TranscriptomicsClinical relevance of DNA microarray analyses using archival formalin-fixed paraffin-embedded breast cancer specimens
This SuperSeries is composed of the following subset Series: GSE23384: Gene profiling using archival formalin-fixed paraffin-embedded breast cancer specimens can generate informative microarray data: A comparison with matched fresh fine needle aspiration biopsy samples (FFPE samples) GSE23385: Gene ...
ORGANISM(S): Homo sapiens 
2011-06-22 | E-GEOD-23386 | biostudies-arrayexpress
ProteomicsComparative proteome stability analysis of snap frozen, RNAlater preserved, and formalin-fixed paraffin-embedded human colon mucosal biopsies
Clinical proteomics research is in part limited by the availability of clinical samples. However, large biobanks exist worldwide containing formalin-fixed and paraffin embedded samples and samples stored in RNAlater. The extraction of proteins for proteome analysis from samples prepared by either me...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080863 | MassIVE
ProteomicsPhosphoproteome Analysis of Formalin-Fixed and Paraffin-Embedded Tissue Sections Mounted on Microscope Slides
Formalin-fixed and paraffin-embedded (FFPE) sections mounted on microscope slides are one of the largest available resources for retrospective research on various diseases, but quantitative phosphoproteome analysis of FFPE sections has never been achieved because of the extreme difficulty of procuri...
ORGANISM(S): Mus Musculus (mouse) 
2016-07-20 | PXD004604 | JPOST Repository
TranscriptomicsRNAseq Analysis of Formalin-Fixed Paraffin-Embedded Prostate Cancer Tissues
In an effort to identify biomarkers of recurrence, we have performed global RNA-sequencing on 106 formalin-fixed, paraffin-embedded (FFPE) prostatectomy samples from 100 patients at three independent sites, and identified a new set of biomarkers of biochemical recurrence composed of a 24-gene panel....
ORGANISM(S): Homo sapiens 
2014-04-11 | E-GEOD-54460 | biostudies-arrayexpress
TranscriptomicsAutomated array-CGH optimized for archival formalin-fixed, paraffin-embedded tumor material
BACKGROUND: Array Comparative Genomic Hybridization (aCGH) is a rapidly evolving technology that still lacks complete standardization. Yet, it is of great importance to obtain robust and reproducible data to enable meaningful multiple hybridization comparisons. Special difficulties arise when aCGH i...
ORGANISM(S): Homo sapiens 
2010-06-12 | E-GEOD-7122 | biostudies-arrayexpress
TranscriptomicsGene profiling using archival formalin-fixed paraffin-embedded breast cancer specimens can generate informative microarray data: A comparison with matched fresh fine needle aspiration biopsy samples (FFPE samples)
The Formalin-Fixed Paraffin-Embedded (FFPE) samples on selected breast cancer subtypes (ER+/Her2-, ER+/Her2+, ER-/Her2+, and ER-/Her2-) and their paired fresh fine needle aspirated biopsies (FNA) were investigated. The cases represented different subtypes of breast cancers based on their clinical re...
ORGANISM(S): Homo sapiens 
2011-06-22 | E-GEOD-23384 | biostudies-arrayexpress
ProteomicsRaw N-glycan MALDI mass spectrometry imaging data on formalin-fixed mouse kidney
The N-glycome was mapped and visualised on formalin-fixed mouse kidney tissue using an ultrafleXtreme MALDI-ToF/ToF MS instrument (Bruker Daltonics).
ORGANISM(S): Mus musculus (Mouse) 
2018-11-02 | PXD009808 | Pride
Formalin-fixed Kidney N-glycan Mouse Maldi Mass spectrometry imaging 
TranscriptomicsExpression Profiling of Formalin-Fixed Parafin-Embedded Primary Breast Tumors
This SuperSeries is composed of the following subset Series: GSE25231: Expression Profiling of Formalin-Fixed Parafin-Embedded Primary Breast Tumors DASL Cancer Panel GSE25233: Expression Profiling of Formalin-Fixed Parafin-Embedded Primary Breast Tumors Whole Genome DASL Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-12-20 | E-GEOD-25234 | biostudies-arrayexpress
TranscriptomicsGene-expression profiles of formalin-fixed, paraffin-embedded human intrahepatic cholangiocarcinoma
BACKGROUND & AIMS: Cholangiocarcinoma, the second most common liver cancer, can be classified as intrahepatic (ICC) or extrahepatic. We performed an integrative genomic analysis of ICC samples from a large series of patients. METHODS: We performed gene expression profile, high-density single nucleot...
ORGANISM(S): Homo sapiens 
2013-01-24 | E-GEOD-32225 | biostudies-arrayexpress
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