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MetabolomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level (Metabolite profiling)

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. The application of omics technologies - mainly studying nucleic acids - has significantly improved MB classification and stratification, but treatment options are still unsatisfactor...

2024-05-30 | MTBLS9830 | MetaboLights
MetabolomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level (Amino acid profiling)

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. The application of omics technologies - mainly studying nucleic acids - has significantly improved MB classification and stratification, but treatment options are still unsatisfactor...

2024-05-30 | MTBLS9836 | MetaboLights
MetabolomicsSerum protein N-glycosylation changes in multiple myeloma

BACKGROUND: Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation changes of these monoclonal immunoglobulins have been reported in multiple myeloma, but previous studies on...

2022-04-27 | MTBLS676 | MetaboLights
ProteomicsN-glycan profiling of Pseudomyxoma peritonei
Pseudomyxoma peritonei (PMP) is a subtype of mucinous adenocarcinoma of the appendix, We compared N-linked glycan profiles of PMP tissues to those of normal appendix. N-glycosidase F liberated N-glycan profiles of eight normal appendix samples and eight low-grade and eight high-grade PMP specimens w...
ORGANISM(S): Homo sapiens (Human) 
2018-08-03 | PXD010086 | Pride
Human appendix cancer n-glycan fucosylation 
GenomicsXBP1s Activation Globally Remodels N-Glycan Structure Distribution Patterns
XBP1s Activation Globally Remodels N-Glycan Structure Distribution Patterns
PRJNA448415 | ENA
MetabolomicsDiagnostic Potential of Plasma IgG N-glycans in Discriminating Thyroid Cancer from Benign Thyroid Nodules and Healthy Controls

BACKGROUND: Novel biomarkers are urgently needed to distinguish between benign and malignant thyroid nodules and detect thyroid cancer in the early stage. The associations between serum IgG N-glycosylation and thyroid cancer risk have been revealed. We aimed to explore the potent...

2021-09-01 | MTBLS2935 | MetaboLights
ProteomicsSerum N-glycomics with nanoLC-QToF LC-MS/MS reveals N-glycan biomarkers for glioblastoma, meningioma, and high-grade meningioma
Alteration of glycosylation in cancer cells leaded to the expression of tumor-associated glycans that could be used as a biomarker for diagnosis and prognostic prediction of the diseases. In this study, we used nanoLC-QToF LC-MS/MS for the identification of serum N-glycan biomarkers for detection of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-03 | MSV000096282 | MassIVE
ProteomicsProfiling the level of N-glycan structural heterogeneity in Arabidopsis N-glycoproteins
In this study, we use hydrophilic enrichment, high-resolution tandem mass spectrometry with complimentary and triggered fragmentation to profile Arabidopsis N-glycopeptides. A total of 492 N-glycosites were identified from 324 Arabidopsis proteins with extensive N-glycan structural heterogeneity rev...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-12-18 | PXD006270 | Pride
Arabidopsis Glycopeptides N-glycosylation 
MetabolomicsN-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression
Various cancers such as colorectal cancer (CRC) are associated with alterations in protein glycosylation. CRC cell lines are frequently used to study these (glyco)biological changes and their mechanisms. However, differences between CRC cell lines with regard to their glycosylation have hitherto bee...
2017-02-03 | MTBLS227 | MetaboLights
ProteomicsN-linked glycan analysis of native SARS-CoV-2 Delta variant Spike
The SARS-CoV-2 Delta variant is more contagious than WT and causes severe symptoms.To understand the elevated fusogenicity of Delta, we used LC-MS/MS to characterize the site specific N-linked glycan of spike protein in SARS-CoV-2 Delta variant virions.The glycan analysis revealed increased oligoman...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2023-05-10 | PXD033342 | Pride
Lc-ms/ms Sars-cov-2 N-linked glycan 
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