Sort   by:  
 Page size 
TranscriptomicsGR and Klf15 regulate gene expression dynamics and integrate signals through feed forward circuitry
The glucocorticoid receptor (GR) regulates adaptive transcriptional programs that alter metabolism in response to stress. Network properties that allow GR to tune gene expression to match specific physiologic demands are poorly understood. We analyzed the transcriptional consequences of GR activatio...
ORGANISM(S): Mus musculus 
2013-05-13 | E-GEOD-44695 | biostudies-arrayexpress
ProteomicsDevelopment of a chemoproteomic platform to identify the sites of (homo)citrullination within complex proteomes
Citrullination and homocitrullination of arginine and lysine can significantly impact protein structure and function. Citrullination of arginine is an enzymatic modification catalyzed by the Protein Arginine Deiminases (PADs). Homocitrullination of lysine is a non-enzymatic modification that occurs ...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-10 | PXD069261 | Pride
Phenylglyoxal Chemoproteomics Desthiobiotin Citrulline Homocitrulline 
UnknownThe coactivator SRC-1 is an essential coordinator of hepatic glucose production.
Not available
S-EPMC3024581 | biostudies-literature
TranscriptomicsTranscriptional dynamics elicited by a short pulse of Notch activation.
Cellular responses to signalling pathways are often highly dynamic, however most analyses of developmental signalling pathways focus on a single endpoint. Here we have analyzed the temporal changes in transcription following a short Notch activation treatment and have related these to the recruitmen...
ORGANISM(S): Drosophila melanogaster 
2012-12-31 | E-GEOD-35557 | biostudies-arrayexpress
GenomicsDefining CD4 T Cell Memory by the Epigenetic Landscape of CpG DNA Methylation [Bisulfite-Seq]
Memory T cells are primed for rapid responses to antigen; however, the molecular mechanisms responsible for priming remain incompletely defined. CpG methylation in promoters is an epigenetic modification, which regulates gene transcription. Using targeted bisulfite sequencing, we examined methylatio...
ORGANISM(S): Homo sapiens 
2015-01-20 | E-GEOD-59858 | biostudies-arrayexpress
UnknownTarget enrichment sequencing coupled with GWAS identifies MdPRX10 as a candidate gene in the control of budbreak in apple.
Not available
S-EPMC10918860 | biostudies-literature
TranscriptomicsCalu6 and LoVo xenograft mRNA expression profiles in response to cediranib treatment
Calu6 and LoVo xenograft mRNA expression profiles in response to cediranib treatment
ORGANISM(S): Homo sapiens 
2013-09-09 | E-MTAB-1627 | biostudies-arrayexpress
TranscriptomicsSingle-cell sequencing of developing human gut reveals transcriptional links to childhood Crohn’s disease
In this study, we performed single-cell transcriptional profiling of human embryonic and fetal gut samples obtained from 9 human embryos spanning ages 6-10 PCW and three regions (duo-jejunum, ileum and colon). Additionally, we profile mucosal biopsies from the terminal ileum of healthy children aged...
ORGANISM(S): Homo sapiens 
2020-12-22 | E-MTAB-8901 | biostudies-arrayexpress
TranscriptomicsRNA-Seq on SOLiD platform of DrosDel deficiency and w1118 flies
RNA-Seq reads of DrosDel deficiency (Df/+) and parental strain diploid flies along with spike-in controls was performed on the SOLiD platform. Samples are named in this dataset according to the following sample naming scheme: tissue_genotype shorthand_sex_biological replicate #_platform_technical re...
ORGANISM(S): Drosophila melanogaster 
2012-04-03 | E-GEOD-31401 | biostudies-arrayexpress
GenomicsApplication of Microdroplet PCR for Large-Scale Targeted Bisulfite Sequencing
Cytosine methylation of DNA CpG dinucleotides in gene promoters is an epigenetic modification that regulates gene transcription. While many methods exist to interrogate methylation states, no current methods offer large-scale, targeted, single CpG resolution. We report an approach combining bisulf...
ORGANISM(S): Homo sapiens 
2011-06-25 | E-GEOD-30179 | biostudies-arrayexpress
Sort   by:  
 Page size