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ProteomicsMycobacterium tuberculosis normoxia hypoxia reactivation with ActivX-desthiobiotin FP probe
Lysates of Mycobacterium tuberculosis (H37Rv auxotroph mc(2)6020) grown under various conditions (normoxia, hypoxia, reactivation from hypoxia) probed the serine hydrolase probe with ActivX-desthiobiotin FP.
ORGANISM(S): Mycobacterium Tuberculosis (ncbitaxon:1773) 
2016-10-10 | MSV000080238 | MassIVE
ProteomicsIsotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome
In the presented datasets, we use newly developed isotopically labeled desthiobiotin azide (isoDTB) tags to residue-specifically quantify cysteines in a variety of bacterial strains and a human cell line with consistently high coverage. We e.g. quantify 59% of all cysteines in essential proteins in ...
ORGANISM(S): Staphylococcus aureus 
2019-12-02 | PXD015457 | Pride
Covalent inhibitors Antibiotics Protein modifications Isotopic labeling Proteomics 
UnknownThe overlooked role of a biotin precursor for marine bacteria - desthiobiotin as an escape route for biotin auxotrophy.
Not available
S-EPMC9561691 | biostudies-literature
UnknownPull-Down of Metalloproteins in Their Native States by Using Desthiobiotin-Based Probes.
Not available
S-EPMC6530555 | biostudies-literature
UnknownIsotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome.
Not available
S-EPMC7027453 | biostudies-literature
UnknownPathway and protein channel engineering of <i>Bacillus subtilis</i> for improved production of desthiobiotin and biotin.
Not available
S-EPMC11648629 | biostudies-literature
TranscriptomicsComparative Analysis of Alkyne- and Desthiobiotinylated Photoaffinity Probes for Chemotranscriptomic Profiling
Understanding small molecule-RNA interactions is a crucial part in drug development and fundamental biology. Chemotranscriptomic profiling is emerging as a powerful platform to interrogate interactions of small molecules with entire transcriptomes. This technique relies on photoaffinity probes that ...
ORGANISM(S): Escherichia coli 
2026-03-18 | GSE318057 | GEO
UnknownDesthiobiotin (DTB)-modified and TAMRA-modified 2″OMeNAD<sup>+</sup> are RNA 2'-phosphotransferase (Tpt1) poisons that enable affinity-tagging and fluorescence-tagging of internal RNA 2'-phosphate groups.
Not available
S-EPMC12621583 | biostudies-literature
ProteomicsDevelopment of a chemoproteomic platform to identify the sites of (homo)citrullination within complex proteomes
Citrullination and homocitrullination of arginine and lysine can significantly impact protein structure and function. Citrullination of arginine is an enzymatic modification catalyzed by the Protein Arginine Deiminases (PADs). Homocitrullination of lysine is a non-enzymatic modification that occurs ...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-10 | PXD069261 | Pride
Phenylglyoxal Chemoproteomics Desthiobiotin Citrulline Homocitrulline 
TranscriptomicsRNA-Seq of A375 cells treated with tetracycline-based crosslinking probes to identify binding sites for the tetracycline analogs Col-3 and doxycycline on the human ribosome
Following the identification of the 80S ribosome as a putative target of the tetracycline analogs Col3 and doxycycline, we next sought to identify the precise binding sites for these tetracyclines within the ribonucleoprotein complex. We incorporated dual bioorthogonal handles into tetracycline-base...
ORGANISM(S): Homo sapiens 
2018-08-30 | E-MTAB-7147 | biostudies-arrayexpress
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