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GenomicsCUT&RUN Targeting c-FOS, c-JUN and SOX2 in neurospheres derived from mouse brain cells
Other than in the development of the brain, SOX2 is essential for the long-term self-renewal of neural stem cells (NSCs). The mechanisms of how SOX2 maintains the stemness of NSCs is not yet understood. We have identified Fos as a downstream target of SOX2, and therefore used CUT&RUN to investigate ...
ORGANISM(S): Mus musculus 
2021-04-01 | E-MTAB-9897 | biostudies-arrayexpress
TranscriptomicsIdentification of candidate genes involved in fructooligosaccharides (FOS) utilization by Lactobacillus paracasei
A shotgun microarray-based approach was used to identify candidate genes encoding the FOS utilization pathway in L. paracasei 1195. Differential expression profiles between cells grown on FOS and glucose provided a basis for identifying genes specifically induced by FOS. In addition, transcription...
ORGANISM(S): Lactobacillus paracasei 
2010-06-30 | E-GEOD-5890 | biostudies-arrayexpress
GenomicsGenome-wide mapping of Fos binding site (K562)
Proto-oncogene c-Fos is a leucine-zipper containing transcription factor which has a DNA binding domain and a transactivation domain. Fos dimerizes with another transcription factor Jun to form AP1 transcription factor. The AP-1 complex has been implicated in transformation and progression of cancer...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-GEOD-19546 | biostudies-arrayexpress
TranscriptomicsInterplay between AP-1 and ERalpha in regulating gene expression and proliferation networks in breast cancer cells
Estrogen receptor alpha (ERalpha) is a ligand-dependent transcription factor that plays an important role in breast cancer. Estrogen-dependent gene regulation by ERalpha can be mediated by interaction with other DNA-binding proteins, such as activator protein-1 (AP-1). The nature of such interaction...
ORGANISM(S): Homo sapiens 
2012-08-05 | E-GEOD-36586 | biostudies-arrayexpress
Transcriptomicsthe influence of a modification of the gut microbiota composition on the hepatic steatosis induced by n-3 polyunsaturated fatty acid (PUFA) depletion
in the present study, we evaluated whether microbiota modulation is able to restore hepatic steatosis induced by n-3 PUFA depletion in mice. For this purpose, mice were fed during three months with a n-3 PUFA-depleted diet (presenting a high n-6/n-3 PUFA ratio), and then supplemented with fructoolig...
ORGANISM(S): Mus musculus 
2012-12-12 | E-GEOD-31727 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat colon from animals fed cellulose vs FOS diets and infected with Salmonella
To increase our knowledge of the effects of Fructo oligosaccharides (FOS) on Salmonella infection in fats, a controlle rat infection study was performed. Two groups of 12 rats were adapted for 14 days to a cellulose diet and one group of 12 rats to a FOS diet. One cellulose-fed group and the FOS-fed...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7472 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse osteoclastogenic splenocytes
Effect of c-fos expression in osteoclastogenic splenocytes.
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-676 | biostudies-arrayexpress
GenomicsRegulation of Megakaryocytic differentiation in Cell Line Models by Dynamic Combinatorial Interactions of RUNX1 with Its Cooperating Partners
Regulation of Megakaryocytic differentiation in Cell Line Models by Dynamic Combinatorial Interactions of RUNX1 with Its Cooperating Partners Examination of RUNX1 binding in K562 cells, before and following TPA induction and CMK cells. Examination of GATA1 and FOS binding and H3K4me1 and H3K27me3 mo...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-24777 | biostudies-arrayexpress
TranscriptomicsEts-domain transcription factor Ets21c and nuclear receptor Ftz-F1 are novel effectors of JNK promoting tumor malignancy
Cancer represents a complex family of diseases, characterized by the uncontrolled malignant growth of a particular cell type and by metastatic dissemination of these transformed cells to secondary sites. The hallmark tumor features emerge as a result of aberrant cellular signaling and pathological g...
ORGANISM(S): Drosophila melanogaster 
2015-11-04 | E-GEOD-65261 | biostudies-arrayexpress
ProteomicsThe Aryl hydrocarbon receptor and FOS mediated cytotoxicity induced by Acenatobacter baumannii
Acinetobacter baumannii is a highly pathogenic and multidrug-resistant Gram-negative bacterium that causes severe nosocomial infections. To better understand the mechanism of pathogenesis, we compare the proteomes of uninfected and infected human cells, revealing that transcription factor FOS is the...
ORGANISM(S): Homo sapiens (Human) 
2024-08-05 | PXD053768 | Pride
Omv Proteome A549 Acenatobacter baumannii 
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