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GenomicsThree distinct patterns of histone H3Y41 phosphorylation mark active genes
The aim of the project was to identify the global distribution of H3Y41ph and correlate its presence with the transcription factor STAT5 and the active histone modification H3K4me3. This was done in human erythroid leukaemia cells (HEL). HEL cells were treated with DMSO or a JAK2 inhibitor (TG101209...
ORGANISM(S): Homo sapiens 
2013-04-15 | E-MTAB-1096 | biostudies-arrayexpress
TranscriptomicsDrosophila MSL complex globally acetylates H4 Lys16 on the male X chromosome for dosage compensation
Drosophila MSL complex binds the single male X chromosome to upregulate gene expression to equal that from the two female X chromosomes. However, it has been puzzling that ~25% of transcribed genes on the X do not stably recruit MSL complex. Here, we find that almost all active genes on the X are ...
ORGANISM(S): Drosophila melanogaster 
2009-06-10 | E-GEOD-14884 | biostudies-arrayexpress
UnknownAntitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742).
Not available
S-EPMC5941615 | biostudies-literature
UnknownAzidoTMT Enables Direct Enrichment and Highly Multiplexed Quantitation of Proteome-Wide Functional Residues.
Not available
S-EPMC10337260 | biostudies-literature
GenomicsGenome-wide analysis of the binding pattern of the transcriptional co-activator Cbp.
The transcriptional coactivator Cbp is critical for hematopoietic stem cell (HSC) development. However, its role in adult HSC and the mechanistic detail of Cbp control of HSC function remain unknown. Using conditional deletion of Cbp in the adult HSC compartment, we demonstrate an altered balance be...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-25265 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Cbp deficient LSK cells
The transcriptional coactivator Cbp is critical for hematopoietic stem cell (HSC) development. However, its role in adult HSC and the mechanistic detail of Cbp control of HSC function remains unknown. Using conditional deletion of Cbp in the adult HSC compartment, we demonstrate an altered balance b...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-25268 | biostudies-arrayexpress
GenomicsThe Transcriptional Programme Controlled by Scl/Tal1 Gene during Early Embryonic Haematopoietic Development
The basic-helix-loop-helix transcription factor Scl/Tal1 controls the development and subsequent differentiation of haematopoietic stem cells (HSCs). However, since few Scl target genes have been validated to date, the underlying mechanisms have remained largely unknown. Here we have employed ChIP...
ORGANISM(S): Mus musculus 
2009-06-19 | E-GEOD-15806 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of breast cancer (HCC1954) and normal breast cells (HMEC)
While genetic mutation is a hallmark of cancer, many cancers also acquire epigenetic alterations during tumorigenesis including aberrant DNA hypermethylation of tumor suppressors as well as changes in chromatin modifications as caused by genetic mutations of the chromatin-modifying machinery. Howeve...
ORGANISM(S): Homo sapiens 
2011-09-16 | E-GEOD-29119 | biostudies-arrayexpress
Genomics5mC Oxidation by Tet2 Modulates Enhancer Activity and Timing of Transcriptome Reprogramming during Differentiation
In mammals, cytosine methylation (5mC) is widely distributed throughout the genome but is notably depleted from active promoters and enhancers. While the role of DNA methylation in promoter silencing has been well documented, the function of this epigenetic mark at enhancers remains unclear. Recent ...
ORGANISM(S): Mus musculus 
2014-09-25 | E-GEOD-48519 | biostudies-arrayexpress
TranscriptomicsaCGH analysis of Palb2GT/+;p53-/- and Palb2+/+;p53-/- lymphomas
Palb2 interacts with BRCA1 and BRCA2 in supercomplexes involved in DNA repair via homologous recombination. Heterozygous germline mutations in PALB2 confer a moderate risk of breast cancer while biallelic PALB2 mutations are linked to a severe form of Fanconi anaemia characterized by early childhood...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-26723 | biostudies-arrayexpress
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