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GenomicsA biochemical basis for toggling enhancers from the active to poised state in B cells
BCL6 is crucial for B-cell activation and lymphomagenesis. We used integrative genomics to explore BCL6 mechanism in normal and malignant B-cells. Surprisingly, BCL6 assembled distinct complexes at enhancers vs. promoters. At enhancers BCL6 preferentially recruited SMRT, which mediated H3K27 deacety...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-29282 | biostudies-arrayexpress
UnknownPeripheral immune cell response to stimulation stratifies Parkinson's disease progression from prodromal to clinical stages.
Not available
S-EPMC12062209 | biostudies-literature
UnknownFAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy.
Not available
S-EPMC6721800 | biostudies-literature
UnknownAutosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology.
Not available
S-EPMC9989348 | biostudies-literature
UnknownRich club analysis in the Alzheimer's disease connectome reveals a relatively undisturbed structural core network.
Not available
S-EPMC4504816 | biostudies-literature
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LK and MS12-inducible)
We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressiv...
ORGANISM(S): Mus musculus 
2010-07-21 | E-GEOD-22773 | biostudies-arrayexpress
UnknownBrain volumetric deficits in MAPT mutation carriers: a multisite study.
Not available
S-EPMC7818091 | biostudies-literature
UnknownENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.
Not available
S-EPMC8805695 | biostudies-literature
UnknownA global database of Holocene paleotemperature records.
Not available
S-EPMC7156486 | biostudies-literature
GenomicsAlzheimer's Disease Sequencing Project (ADSP)

The overarching goals of the ADSP are to: (1) identify new genomic variants contributing to increased risk of developing AD, (2) identify new genomic variants contributing to protection against developing AD, and (3) provide insight as to why individuals with known risk factor variants escape fro...

phs000572.v1.p1 | EGA
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