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GenomicsERa-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer
This SuperSeries is composed of the following subset Series: GSE22533: Breast cancer cells resistant to hormone deprivation maintain an estrogen receptor alpha-dependent, E2F-directed transcriptional program GSE27300: Estrogen-independent genomic ER binding analysis Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-05-14 | E-GEOD-37955 | biostudies-arrayexpress
GenomicsAnalysis of MIZ1, MYC-ER and MYC-ERVD binding sites in MCF10A cells
Oncogenic levels of Myc expression sensitize cells to multiple apoptotic stimuli and this protects long-lived organisms from cancer development. How cells discriminate physiological from supra-physiological levels of Myc is largely unknown. Here we show that induction of apoptosis by Myc in breast e...
ORGANISM(S): Homo sapiens 
2015-07-10 | E-GEOD-59146 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rice transgenics expressing rice full-length cDNAs vs wild-type Col-0
We generated more than 23,000 independent Arabidopsis transgenic lines that expressed rice fl-cDNAs (Rice FOX Arabidopsis lines). The short generation time and rapid and efficient transformation frequency of Arabidopsis enabled the functions of the rice genes to be analyzed rapidly. We screened rice...
ORGANISM(S): Arabidopsis thaliana 
2008-12-05 | E-GEOD-13165 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of estrogen receptor positive breast cancer cell lines after long term estrogen deprivation
Hyperactivation of phosphatidylinositol-3 kinase (PI3K) promotes escape from hormone dependence in estrogen receptor-positive breast cancer. A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation. We used gene expression microarrays to identify genes...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-19639 | biostudies-arrayexpress
TranscriptomicsBreast cancer cells resistant to hormone deprivation maintain an estrogen receptor alpha-dependent, E2F-directed transcriptional program
A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation. To model resistance to aromatase inhibitor (AI) therapy, long-term estrogen-deprived (LTED) derivatives of MCF-7 and HCC-1428 cells were generated through culture for 3 and 7 months under hormone...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-22533 | biostudies-arrayexpress
UnknownHER2-enriched subtype and novel molecular subgroups drive aromatase inhibitor resistance and an increased risk of relapse in early ER+/HER2+ breast cancer.
Not available
S-EPMC9482930 | biostudies-literature
UnknownNeoadjuvant Chemotherapy with Accelerated Methotrexate, Vinblastine, Doxorubicin, and Cisplatin in Patients with Muscle-invasive Bladder Cancer: A Retrospective Age-stratified Analysis on Safety and Efficacy.
Not available
S-EPMC10733961 | biostudies-literature
UnknownAging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress.
Not available
S-EPMC9534504 | biostudies-literature
UnknownNeoadjuvant Dose-dense Gemcitabine and Cisplatin in Muscle-invasive Bladder Cancer: Results of a Phase 2 Trial.
Not available
S-EPMC6226048 | biostudies-literature
UnknownAccelerated methotrexate, vinblastine, doxorubicin, and cisplatin is safe, effective, and efficient neoadjuvant treatment for muscle-invasive bladder cancer: results of a multicenter phase II study with molecular correlates of response and toxicity.
Not available
S-EPMC4050203 | biostudies-literature
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