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ProteomicsFox serum proteomics analysis suggests host-specific responses to Angiostrongylus vasorum infection
Dogs infected with the cardiopulmonary nematode Angiostrongylus vasorum may suffer respiratory distress and/or bleeding disorders. Descriptions of clinical signs in foxes are rare, despite high prevalence. To evaluate the impact of infection on coagulation and immune response, serum proteins from ei...
ORGANISM(S): Vulpes vulpes (Red fox) 
2021-11-25 | PXD028312 | Pride
Proteomics Angiostrongylus vasorum Vulpes vulpes Immune response Coagulation Fox 
TranscriptomicsTranscriptional Response of 0.1%YE-grown M. sedula cells to ferrous sulfate
(from abstract): Iron oxidation is a desirable trait of biomining microorganisms, although the mechanism is not well-understood in extreme thermoacidophiles. The complete genome sequence of the extremely thermoacidophilic archaeon Metallosphaera sedula DSM 5348 (2.2 Mb, ~2300 ORFs) provides insights...
ORGANISM(S): Metallosphaera sedula 
2008-05-02 | E-GEOD-11296 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of aortic arches from smooth muscle cell–specific Hif1a knockout and control mice with atherosclerosis
Smooth muscle cells (SMCs) undergo phenotypic switching during atherosclerosis and give rise to a large fraction of plaque cells. To investigate the role of hypoxia-inducible factor 1α (HIF1α) signaling in SMC behaviour during atherogenesis, we used mice in which Hif1a is conditionally deleted in li...
ORGANISM(S): Mus musculus 
2026-06-21 | E-MTAB-17142 | biostudies-arrayexpress
GenomicsCistrome of the Aldosterone-activated Mineralocorticoid Receptor in Human Renal Cells
Aldosterone, the main mineralocorticoid hormone in Humans, has a major role in maintaining the hemo-electrolytique homeostasis, by acting in the distal part of nephron. This steroid hormone mainly acts through its binding to a ligand-induced transcription factor, the mineralocorticoid receptor (MR)....
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-69777 | biostudies-arrayexpress
TranscriptomicsGenomic Redistribution of GR Monomers and Dimers Mediates the Transcriptional Response to Exogenous Glucocorticoid In Vivo.
Expression profiles of GRdim mutant macrophages (mouse, bone-marrow derived) treated with LPS for 6 hrs or with LPS (6hrs) + Dex (O/N 1uM). Identification of GR-regulated genes in response to LPS. 3 Grdim mutant macrophages samples treated with LPS (6hrs) and 3 Grdim mutant macrophage samples treate...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-68160 | biostudies-arrayexpress
TranscriptomicsActivating transcription factor 3 regulates immune and metabolic homeostasis
Integration of metabolic, stress and immune responses plays a fundamental role during animal development to maintain energy homeostasis while ensuring growth and proper developmental timing. Perturbation of metabolic and immune signaling circuits has detrimental consequences to animal development in...
ORGANISM(S): Drosophila melanogaster 
2012-11-05 | E-GEOD-36377 | biostudies-arrayexpress
GenomicsIncreased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis (RRBS)
The de novo DNA methyltransferases Dnmt3a and Dnmt3b are of crucial importance in hematopoietic stem cells, and Dnmt3b has recently been shown to play a role in genic methylation. Forced Dnmt3b expression induced widespread DNA hypermethylation in myc-bcl2 induced leukemias, especially at promoters ...
ORGANISM(S): Mus musculus 
2016-01-11 | E-GEOD-71039 | biostudies-arrayexpress
TranscriptomicsRNA-seq of rat NSCs stimulated with lithium and/or photon radiation.
Investigation of lithium effects in rat neural stem cells exposed to irradiation to mimic cranial radiotherapy in children. We investigated whether lithium is involved in halting or even preventing gene expression regulation in the model system.
ORGANISM(S): Rattus norvegicus 
2019-10-01 | E-MTAB-7238 | biostudies-arrayexpress
GenomicsFGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency
Genome-wide erasure of DNA methylation takes place in primordial germ cells (PGCs) and early embryos but the signalling mechanisms that induce reprogramming are unknown. Here we show that inhibition of Erk1/2 and Gsk3bM-BM- signalling in mouse embryonic stem cells (ESCs) by small molecule inhibitors...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-42923 | biostudies-arrayexpress
TranscriptomicsDNMT1-associated long non-coding RNA regulate global gene expression and DNA methylation in colon cancer
The investigation of the association of long non-coding RNAs (lncRNAs) with DNMT1 by RIP-seq reveals that DNMT1 interacts with DACOR1. We identified the genomic occupancy sites of DACOR1 through ChIRP-seq, which we found to significantly overlap with known differentially methylated regions (DMRs) in...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-58989 | biostudies-arrayexpress
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