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TranscriptomicsDeep sequencing of human naive CD4 T cells identifies miR-34c-5p as a novel regulator of T cell activation and HIV replication
Cell activation is a vital step for T cell memory/effector differentiation as well as for productive HIV infection. To identify novel regulators of this process, we used next generation sequencing to profile changes in microRNA expression occurring in purified human naive CD4 T cells in response to ...
ORGANISM(S): Homo sapiens 
2016-12-21 | E-MTAB-4214 | biostudies-arrayexpress
TranscriptomicsRequirement for Shh and Fox family genes at different stages in sweat gland development
Sweat glands play a fundamental role in thermal regulation in man, but the molecular mechanism of their development remains unknown. To initiate analyses, we compared the model of Eda mutant Tabby mice, in which sweat glands were not formed, to wild-type mice. We inferred developmental stages and c...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-14907 | biostudies-arrayexpress
TranscriptomicsIdentification of a tumor suppressor network in T-cell leukemia.
In T-cell acute lymphoid leukemia (T-ALL) several oncogenes and tumour suppressor (TS) genes have been described. Deregulation of these genes mostly results from genomic aberrations, including translocations, amplifications and deletions. To identify novel cancer-related genes targeted by copy numbe...
ORGANISM(S): Homo sapiens 
2017-02-01 | E-MTAB-5232 | biostudies-arrayexpress
ProteomicsFox serum proteomics analysis suggests host-specific responses to Angiostrongylus vasorum infection
Dogs infected with the cardiopulmonary nematode Angiostrongylus vasorum may suffer respiratory distress and/or bleeding disorders. Descriptions of clinical signs in foxes are rare, despite high prevalence. To evaluate the impact of infection on coagulation and immune response, serum proteins from ei...
ORGANISM(S): Vulpes vulpes (Red fox) 
2021-11-25 | PXD028312 | Pride
Proteomics Angiostrongylus vasorum Vulpes vulpes Immune response Coagulation Fox 
TranscriptomicsVitamin A-deficient mice experience increased viral antigens and enhanced cytokine/chemokine production in nasal tissues following respiratory virus infection despite the presence of FoxP3+ T cells
Vitamin A deficiencies and insufficiencies affect hundreds of millions of people in both developing and developed countries. These individuals experience higher rates of mortality and increased morbidity during enteric and respiratory infections compared to those who are vitamin A sufficient. Previo...
ORGANISM(S): Mus musculus 
2016-02-11 | E-GEOD-65805 | biostudies-arrayexpress
TranscriptomicsScreening RNA from human uninfected macrophages, activated macrophages and T cells
The Fox laboratory studies the SIV infection of rhesus monkeys as a model for HIV/AIDS, focusing on central nervous system infection, immunity, and brain dysfunction that develops following infection. Previous Fox lab data shows that virions derived from macrophages and T-cells differ in infectivity...
ORGANISM(S): Homo sapiens 
2011-04-29 | E-GEOD-28928 | biostudies-arrayexpress
TranscriptomicsAllogeneic mature human dendritic cells generate superior alloreactive regulatory T cells in the presence of IL-15
Introduction: Expansion of antigen (Ag)-specific natural occurring regulatory T cells (nTregs) is required to obtain sufficient numbers of cells for cellular immunotherapy. In this study, different allogeneic stimuli were studied for their capacity to generate functional alloAg-specific nTregs. Meth...
ORGANISM(S): Homo sapiens 
2015-04-20 | E-GEOD-66385 | biostudies-arrayexpress
TranscriptomicsRequirement for Shh and Fox family genes at different stages in sweat gland development (E17.5)
Sweat glands play a fundamental role in thermal regulation in man, but the molecular mechanism of their development remains unknown. To initiate analyses, we compared the model of Eda mutant Tabby mice, in which sweat glands were not formed, to wild-type mice. We inferred developmental stages and c...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-14872 | biostudies-arrayexpress
TranscriptomicsRequirement for Shh and Fox family genes at different stages in sweat gland development (E16.5)
Sweat glands play a fundamental role in thermal regulation in man, but the molecular mechanism of their development remains unknown. To initiate analyses, we compared the model of Eda mutant Tabby mice, in which sweat glands were not formed, to wild-type mice. We inferred developmental stages and c...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-14871 | biostudies-arrayexpress
TranscriptomicsRequirement for Shh and Fox family genes at different stages in sweat gland development (E15.5)
Sweat glands play a fundamental role in thermal regulation in man, but the molecular mechanism of their development remains unknown. To initiate analyses, we compared the model of Eda mutant Tabby mice, in which sweat glands were not formed, to wild-type mice. We inferred developmental stages and c...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-14870 | biostudies-arrayexpress
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