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GenomicsFOXM1 Cistrome Predicts Breast Cancer Metastatic Outcome Better Than FOXM1 Expression Levels or Tumor Proliferation Index [ChIP-Seq]
FOXM1 is a key transcription factor regulating cell cycle progression, DNA damage response, and a host of other hallmark cancer features, but the role of the FOXM1 cistrome in driving estrogen receptor-positive (ER+) vs. ER- breast cancer clinical outcomes remains undefined. Chromatin immunoprecipit...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-72977 | biostudies-arrayexpress
GenomicsFOXM1 ChIP-seq in an OE33 cell line
Chromatin immunoprecipitation using anti-FOXM1 (Santa Cruz Biotechnology: sc- 502X) antibodies in an OE33 cell line
ORGANISM(S): Homo sapiens 
2015-12-14 | E-MTAB-4121 | biostudies-arrayexpress
GenomicsIdentification of cell cycle-regulated genes periodically expressed in U2OS cells and their regulation by FOXM1 and E2F transcription factors [ChIP-seq]
We report the genome wide DNA binding patterns of wild type FOXM1 in asynchronous HeLa cells using chromatin precipitation followed by high-throughput sequencing (ChIP-seq). We find that FOXM1 is bound to the promoter of a number of cell cycle genes including PLK, AURKB, and CCNB1. FOXM1 ChIP-seq i...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-52098 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cells expressing FoxM1-ER fusion protein
Experiment description To identify FoxM1-regulated genes, we carried out gene expression profile analysis after inducible activation of a FoxM1-ER fusion protein using high-density human cDNA microarrays. We constructed a stable line of U2OS cells expressing full-length HA-FoxM1 fused at its C-term...
ORGANISM(S): Homo sapiens 
2005-01-01 | E-MEXP-230 | biostudies-arrayexpress
TranscriptomicsFOXM1 Cistrome Predicts Breast Cancer Metastatic Outcome Better Than FOXM1 Expression Levels or Tumor Proliferation Index [RNA-Seq]
FOXM1 is a key transcription factor regulating cell cycle progression, DNA damage response, and a host of other hallmark cancer features, but the role of the FOXM1 cistrome in driving estrogen receptor-positive (ER+) vs. ER- breast cancer clinical outcomes remains undefined. Chromatin immunoprecipit...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-73370 | biostudies-arrayexpress
TranscriptomicsFOXM1 Orchestrates a Global Methylation Signature that Mimics the Cancer Epigenome
Aberrant upregulation of a single oncogene FOXM1 in primary normal human oral epithelial cells orchestrated a cancer-like methylome landscape This study have identified a unique FOXM1-induced epigenetic signature which may have potentials as biomarkers for early oral cancer screening, diagnostic and...
ORGANISM(S): Homo sapiens 
2012-04-18 | E-GEOD-31767 | biostudies-arrayexpress
TranscriptomicsGene expression profile of FOXM1 with Doxorubicin in MDA-MB-231 breast cancer cells
Transcription factors (TFs) play a crucial role in diverse cellular physiology by controlling down-stream target genes. It has been well recognized that TFs are attractive target for treating human cancer since transcriptional activity or gene expression level of TFs can be directly modulated. To ex...
ORGANISM(S): Homo sapiens 
2012-05-14 | E-GEOD-25741 | biostudies-arrayexpress
TranscriptomicsFoxM1 is essential for quiescence and maintenance of hematopoietic stem cell
FoxM1, a mammalian Forkhead Box M1 protein, is known as a typical proliferation-associated transcription factor that regulates of G1/S and G2/M transition in the proliferating cells. However, the in vivo function of FoxM1 in adult stem cells remains unknown. Here, we found that FoxM1 is highly expr...
ORGANISM(S): Mus musculus 
2015-06-15 | E-GEOD-62360 | biostudies-arrayexpress
GenomicsGenome-wide mapping of FOXM1 binding sites
There are nearly fifty forkhead (FOX) transcription factors encoded in the human genome and due to sharing a common DNA binding domain, they are all thought to bind to similar DNA sequences. It is therefore unclear how these transcription factors are targeted to specific chromatin regions to elicit ...
ORGANISM(S): Homo sapiens 
2012-11-05 | E-GEOD-38170 | biostudies-arrayexpress
ProteomicsIdentification of FOXM1 Epitopes in Lung Cancer
FOXM1 is highly expressed in various cancer types and considered a key driver of cancer progression. Accordingly, we evaluated the immunogenicity of FOXM1 and investigated the feasibility of targeting this transcription factor using T cell receptor (TCR) engineering. We identified epitopes derived f...
ORGANISM(S): Homo sapiens (Human) 
2026-02-18 | PXD073612 | Pride
Immunopeptidomics Foxm1 Lung cancer 
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