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TranscriptomicsThe FoxO signature in protein breakdown
Under stress conditions mammalian cells activate compensatory mechanisms to survive and maintain cellular function. During catabolic conditions, such as low nutrients, systemic inflammation, cancer or infections, protein breakdown is enhanced and aminoacids are released from muscles to sustain liver...
ORGANISM(S): Mus musculus 
2015-04-24 | E-GEOD-52667 | biostudies-arrayexpress
ModelsSmith2010 - Response of FOXO Transcription Factors to Post-Translational Modifications Made by Ageing-Related Signalling Pathways
Graham R. Smith & Daryl P. Shanley. Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways. PLoS ONE 5, 6 (2010). FOXO transcription factors are an important, conserved family of regulators of cellular processes i...
2024-09-02 | BIOMD0000000705 | BioModels
TranscriptomicsEndogenous DAF-16 genome-wide recruitment under low Insulin signalling condition in Caenorhabditis elegans
In order to understand the complexity of gene regulation downstream of IIS, we did RNA-seq in mixed culture in wild-type, daf-2(e1370), daf-16(mgDf50);daf-2(e1370) and daf-2(e1370);daf-12(m20 and correlated it with ChIP-seq data RNA-seq profile of different mutants in mix stage
ORGANISM(S): Caenorhabditis elegans 
2016-03-01 | E-GEOD-67975 | biostudies-arrayexpress
ModelsSmith2010 - Response of FOXO Transcription Factors to Post-Translational Modifications (with acetylation pathway)
Graham R. Smith & Daryl P. Shanley. Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways. PLoS ONE 5, 6 (2010). FOXO transcription factors are an important, conserved family of regulators of cellular processes i...
2024-09-02 | BIOMD0000000706 | BioModels
TranscriptomicsFoxo1/3-deficient Treg cells
Identification of Foxos target genes in Treg cells. Foxo1and Foxo3 are transcription factors of Foxo family. CD4+Foxp3+ Treg cells isolated from wild-type and Foxo1/3-deficient mice were analyzed by global gene expression profiling. Results indicate Foxos regulate expression of a subset of Treg cell...
ORGANISM(S): Mus musculus 
2010-09-13 | E-GEOD-21678 | biostudies-arrayexpress
TranscriptomicsExpression data from skeletal muscles of flies with muscle-specific overexpression of Foxo or Mnt
Skeletal muscle senescence influences whole organism aging, yet little is known on the relay of pro-longevity signals from muscles to other tissues. We performed an RNAi screen in Drosophila for muscle-released cytokines ('myokines') regulating lifespan and identified Myoglianin, the homolog of huma...
ORGANISM(S): Drosophila melanogaster 
2014-07-02 | E-GEOD-39877 | biostudies-arrayexpress
TranscriptomicsdFOXO targets in Drosophila melanogaster
dFOXO targets in adult Drosophila melanogaster females, and the effect of insulin signalling and stress on binding. The experimets determined the binding locations of dFOXO in the whole adult female fly using ChIP-chip. The protocol was validated using mock conditions: pre-immune serum or IP on chro...
ORGANISM(S): Drosophila melanogaster 
2011-06-18 | E-TABM-751 | biostudies-arrayexpress
ModelsSmith2013 - Regulation of Insulin Signalling by Oxidative Stress
Smith2013 - Regulation of Insulin Signalling by Oxidative Stress The model describes insulin signalling (in rodent adipocytes), which includes in addition to the core pathway, the transcriptional feedback through the Forkhead box type O (FOXO) transcription factor and interaction w...
2024-09-02 | BIOMD0000000474 | BioModels
Transcriptomicsdaf-16/FoxO isoform-specific deletion mutants
FoxO transcription factors promote longevity across taxa. How they do so is poorly understood. In the nematode Caenorhabditis elegans, the A- and F-isoforms of the FoxO transcription factor DAF-16 extend life span in the context of reduced DAF-2 insulin-like growth factor receptor (IGFR) signaling. ...
ORGANISM(S): Caenorhabditis elegans 
2015-08-27 | E-GEOD-72426 | biostudies-arrayexpress
TranscriptomicsCP003: Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy
The PI3K-PKB/c-akt-FOXO signalling network provides a major intracellular hub for regulation of cell proliferation, survival and stress resistance1. Here we report a novel function for FOXO transcription factors in regulating autophagy through modulation of intracellular glutamine levels. To identif...
ORGANISM(S): Mus musculus 
2012-07-21 | E-GEOD-35703 | biostudies-arrayexpress
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