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TranscriptomicsMethylation arrays (MethylationEPIC) of longitudinal cord and peripheral blood from children aged 0, 5 and 10 years old
Extensive epigenetic remodelling takes place during early life; however, the alterations of DNA methylation that occur during this period have not been sufficiently addressed by longitudinal studies. We made use of the most recent Illumina MethylationEPIC Beadchip platform to characterize genome-wid...
ORGANISM(S): Homo sapiens 
2019-01-07 | E-MTAB-7069 | biostudies-arrayexpress
TranscriptomicsHigh-throughput pyrosequencing of endogenous small RNAs from Arabidopsis thaliana wild-type and ddm1 mutant.
DNA methylation is essential for silencing transposable elements and some genes in higher eukaryotes, implying that this modification must be tightly controlled. However, accidental changes in DNA methylation can be transmitted through mitosis, as in cancer, or meiosis, leading to epiallelic variati...
ORGANISM(S): Arabidopsis thaliana 
2009-02-02 | E-GEOD-13419 | biostudies-arrayexpress
GenomicsThe DNA methylomes of a newborn and a centenarian
We have developed Whole Genome Bisulfite Sequencing (WGBS) of a newborn and a centenarian to address the epigenetic drifts in human aging, which might be an alternative pathway to explain the age-associated alterations. In addition, we have analyzed the methylome of a middle-age donor (26 years). Ex...
ORGANISM(S): Homo sapiens 
2012-06-13 | E-GEOD-31263 | biostudies-arrayexpress
TranscriptomicsMethylation arrays elucidate 5mC and 5hmC levels of human glioblastoma cell line LN229 upon restoration of TET3 expression.
DNA hydroxymethylation is frequently lost in glioblastoma. We hypothesized that reduced 5hmC levels might be related to the impaired expression of TET proteins in brain tumors. In this study we performed a genome-wide methylation analysis of LN229 cells stably transfected with scramble or TET3 overe...
ORGANISM(S): Homo sapiens 
2018-03-03 | E-MTAB-6001 | biostudies-arrayexpress
TranscriptomicsDNA Methylation Biomarkers for Noninvasive Diagnosis of Colorectal Cancer
DNA methylation in colorectal cancer diagnosis. The Illumina GoldenGate Methylation Cancer Panel I was used to select a set of candidates markers informative of colorectal cancer diagnosis from 807 cancer-related genes. In the discovery phase, tumor tissue and paired adjacent normal mucosa from 92 c...
ORGANISM(S): Homo sapiens 
2013-05-27 | E-GEOD-43369 | biostudies-arrayexpress
TranscriptomicsThe DNA Methylomes of a Newborn and a Centenarian
Examination of two DNA methylomes at the most extreme points of their lives to see differences that might contribute to explain the aged phenotype We have performed Whole Genome Bisulfite Sequencing (WGBS) and methylation array technology of newborn and a centenarian samples to address the Epigeneti...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-31438 | biostudies-arrayexpress
TranscriptomicsDNA methylation differences between Newborns and Nonagenarians [PBMNC]
Human aging implies many phenotypic modifications and an increased susceptibility to many common diseases, phenomena that cannot be fully explained by the constrained genetic setting. An alternative pathway that could explain the age-associated alterations is epigenetic drifts. To address this issue...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-33233 | biostudies-arrayexpress
TranscriptomicsDNA methylomes of Newborns and Nonagenarians
DNA methylation differences between Newborns and Nonagenarians The study aimed to compare the DNA methylation differences between newborns and nonagenarians using methylation array technology (450K, Illumina). The identified differently methylated CpG were further analyzed for their presence in dise...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-30870 | biostudies-arrayexpress
TranscriptomicsChanges in the Pattern of DNA Methylation Associate with Twin Discordance in SLE
This is the first high-throughput analysis of DNA methylation in autoimmune diseases. We have used a cohort of MZ twins discordant for three diseases whose clinical signs often overlap: systemic lupus erythematosus (SLE), rheumatoid arthritis and dermatomyositis. Only MZ twins discordant for SLE fea...
ORGANISM(S): Homo sapiens 
2009-11-16 | E-GEOD-19033 | biostudies-arrayexpress
UnknownEpigenetic inactivation of the premature aging Werner syndrome gene in human cancer.
Not available
S-EPMC1466544 | biostudies-literature
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