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MetabolomicsMolecular networking coupled to high-resolution mass spectrometry fragmentation reveals a multitude of urinary antihypertensive drug metabolites
Mass spectrometry is the current technique of choice in studying drug metabolism. High-resolution mass spectrometry (HR-MS) in combination with fragment analysis (MS/MS) has the potential to contribute to rapid advances in this field. However, the data emerging from such fragmentation spectra pose c...
2016-05-23 | MTBLS307 | MetaboLights
ProteomicsStability of peptide fragmentation patterns
Our study aims to determine the stability of fragmetnation patterns of peptides upon collision-induced dissociation (CID). Recent studies reported that for a minority of peptides, CID fragmentation leads to non-reproducible fragmentation spectra and therefore impaired identification. In order to stu...
ORGANISM(S): Homo sapiens (Human) 
2019-02-25 | PXD006691 | Pride
Peptide fragmentation Peptide identification Collision-induced dissociation Tandem ms 
GenomicsSpatial co-fragmentation pattern of cell-free DNA recapitulates in vivo chromatin organization and identifies tissue-of-origin
Spatial co-fragmentation pattern of cell-free DNA recapitulates in vivo chromatin organization and identifies tissue-of-origin
PRJNA514727 | ENA
ProteomicsProtease-sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation
In this study we aimed to provide a detailed comparative description of the fragmentation sites of amyloid LCs in multiple organs of an individual patient.
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD025185 | Pride
Proteolysis Amyloidogenesis Amyloid fibrils Proteomics Immunoglobulin light chains 
GenomicsDetection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients
Glioma is difficult to detect or characterise using current liquid biopsy approaches. Detection of cell-free tumor DNA (cftDNA) in cerebrospinal fluid (CSF) has been proposed as an alternative to detection in plasma. We used shallow whole-genome sequencing (sWGS, at a coverage of < 0.4x) of cell-fr...
EGAS00001003255 | EGA
ProteomicsGenotyping-by-sequencing-based identification of Arabidopsis pattern recognition receptor RLP32 recognizing proteobacterial translation initiation factor IF1
Pattern-triggered immunity (PTI) is a central component of plant immunity. Activation of PTI relies on the recognition of microbe-derived structures, termed patterns, through plant encoded surface-resident pattern recognition receptors (PRRs). We have identified proteobacterial translation initiatio...
ORGANISM(S): Escherichia coli 
2022-03-03 | PXD031124 | Pride
Pattern recognition receptor Proteobacterial protein translation initiation factor 1 Plant immunity 
UnknownRectal tumor fragmentation as a response pattern following chemoradiation.
Not available
S-EPMC9830359 | biostudies-literature
UnknownFragmented mitochondrial genomes of the rat lice, Polyplax asiatica and Polyplax spinulosa: intra-genus variation in fragmentation pattern and a possible link between the extent of fragmentation and the length of life cycle.
Not available
S-EPMC3901344 | biostudies-literature
ProteomicsEnrichment and Fragmentation Approaches for Enhanced Detection and Characterization of Endogenous Glycosylated Neuropeptides
Glycosylation, a common and heterogeneous post-translational modification plays a key role in altering biomolecule function and other properties. Prior to monitoring regulatory roles, basal glyconeuropeptide expression must be determined. Characterization is partially limited by the lower abundance ...
ORGANISM(S): Callinectes sapidus 
2022-08-19 | PXD033226 | Pride
Glycosylation Neuropeptides Endogenous peptides Mass spectrometry De novo sequencing 
MetabolomicsPublic LC-Orbitrap-MS/MS Spectral Library for Metabolite Identification

Liquid chromatography-mass spectrometry (LC-MS)-based untargeted metabolomics studies require high-quality spectral libraries for reliable metabolite identification. We have constructed EMBL-MCF (European Molecular Biology Laboratory-Metabolomics Core Facility), an open LC-MS/MS spectral library ...

2020-09-28 | MTBLS1861 | MetaboLights
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