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ProteomicsThe short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting
Programmed ribosomal frameshifting (PRF) is a fundamental gene expression event in many viruses, including SARS-CoV-2. It allows production of essential viral structural and replicative enzymes that are encoded in an alternative reading frame. Despite the importance of PRF for the viral life cycle, ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD029656 | Pride
Frameshifting Sars-cov-2 Translation regulation 
GenomicsMassively parallel reporter assay for programmed ribosomal frameshifting on designed sequence libraries
Massively parallel reporter assay for programmed ribosomal frameshifting on designed sequence libraries
PRJNA607955 | ENA
GenomicsStart codon-associated ribosomal frameshifting mediates nutrient stress adaptation
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation
PRJNA766610 | ENA
GenomicsStructural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome
Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome
PRJNA704627 | ENA
TranscriptomicsRiboSeq of BSR cells infected at MOI 3 with Theiler's murine encephalomyelitis virus, compared to mock-infected controls, harvested at 10 hpi
BSR cells were infected with the Cardiovirus B archetype, Theiler’s murine encephalomyelitis virus (TMEV), and mutants thereof, and subjected to ribosome profiling to analyse the viral translatome, frameshifting, and ribosome pausing events. Samples were harvested at 10 hpi by flash-freezing, withou...
ORGANISM(S): Mesocricetus auratus 
2021-11-10 | E-MTAB-9438 | biostudies-arrayexpress
OtherStructural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome
Programmed ribosomal frameshifting is the key event during translation of the SARS-CoV-2 RNA genome allowing synthesis of the viral RNA-dependent RNA polymerase and downstream viral proteins. Here we present the cryo-EM structure of the mammalian ribosome in the process of translating viral RNA paus...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2021-05-17 | GSE167421 | GEO
GenomicsRibosomal frameshifting at normal codon repeats recodes functional chimeric proteins in human [RNA-seq]
Ribosomal frameshifting at normal codon repeats recodes functional chimeric proteins in human [RNA-seq]
PRJNA910966 | ENA
GenomicsRibosomal frameshifting at normal codon repeats recodes functional chimeric proteins in human[ChIP-seq]
Ribosomal frameshifting at normal codon repeats recodes functional chimeric proteins in human[ChIP-seq]
PRJNA910965 | ENA
OtherMassively parallel reporter assay for programmed ribosomal frameshifting on designed sequence libraries
We designed an oligonucleotide libraries containing a potential frameshifting site, cloned the library variants into a dedicated reporter construct, transfected and integrated these constructs in the genome of K562 cells, and performed FACSseq (as well as targeted RNA sequencing) to determine if and...
ORGANISM(S): Homo sapiens 
2020-02-22 | GSE145684 | GEO
GenomicsHidden stop codons dictate mRNA fate by ambushing ribosomal frameshifting
Hidden stop codons dictate mRNA fate by ambushing ribosomal frameshifting
PRJNA1295776 | ENA
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