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TranscriptomicsMyeloid lineage switch in pro-B cells generates novel macrophage subsets during homeostasis and inflammation
Here we demonstrate for the first time evidence of lineage switch from B-1 B lymphocyte to a macrophage , or so-called transdifferentiation, occurring in mature cells in vivo. Specifically, using transgenic B6.Mb1-iCre/Rosa26-YFP mice, in which YFP expression is restricted exclusively to B cell line...
ORGANISM(S): Mus musculus 
2018-09-01 | E-MTAB-1878 | biostudies-arrayexpress
UnknownFirst-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer.
Not available
S-EPMC5648176 | biostudies-literature
TranscriptomicsMethylome of 9 canine transmissible veneral tumour (CTVT) samples
The canine transmissible veneral tumour (CTVT) is one of the few known clonally transmissible cancers in nature. CTVT regresses spontaneously or after a single treatment with vincristine, however we know little of the mechanisms. To understand CTVT regression, we performed methylome analyses on seri...
ORGANISM(S): Canis lupus familiaris 
2018-01-31 | E-MTAB-5495 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed human and viral miRNAs across a panel of B-cell lines, including primary effusion lymphomas
To identify differentially expressed human and viral miRNAs across a panel of B-cell lines, including several primary effusion lymphomas (PEL). Gammaherpesvirus and host cell microRNAs (miRNAs) together modulate gene expression in normal and malignant cells. Using microRNA microarrays, we determined...
ORGANISM(S): Homo sapiens 
2015-12-05 | E-GEOD-18437 | biostudies-arrayexpress
TranscriptomicsOver-expression of hsa-miR-221 in JSC1 cells and identification of miRNA targets expressed in a panel of B-cell lines
1) To identify changes in gene expression upon over-expression of hsa-miR-221 in JSC1 cells. 2) To identify human miRNA targets expressed in a panel of B-cell lines. Gammaherpesvirus and host cell microRNAs (miRNAs) together modulate gene expression in normal and malignant cells. Using microRNA micr...
ORGANISM(S): Homo sapiens 
2015-12-05 | E-GEOD-18438 | biostudies-arrayexpress
TranscriptomicsGene expression change in cyclin D1 -/- retinas in comparison to wildtype.
Cyclin D1 belongs to the core cell cycle machinery1, and it is frequently overexpressed in human cancers2. The full repertoire of cyclin D1 functions in normal development and in cancer cells is currently unknown. To address this question, here we introduce a novel approach that allows one to deter...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-13635 | biostudies-arrayexpress
TranscriptomicsAnalyses of cyclin D1 function using a "genetic-proteomic" approach
We examined the transcriptional function of cyclin D1 in mouse development using two approaches. First, we queried association of cyclin D1 with the genome of E14.5 mouse embryos using ChIP-on-chip approach. We observed binding of cyclin D1 to several promoter regions. Second, we compared gene exp...
ORGANISM(S): Mus musculus 
2010-01-28 | E-GEOD-13636 | biostudies-arrayexpress
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