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TranscriptomicsTranscription profiling of human fat samples from gastric bypass patients
Fat tissue was resected during gastric bypass surgery for management of obesity. All subjects had fasted at least 10 hours before surgery. Subjects with malignancies were excluded. No subjects were taking thiazolidinediones or steroids. None had fasting plasma glucose levels over 120 mg/ dl. One ha...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-1657 | biostudies-arrayexpress
TranscriptomicsExpression and ChIP-chip data from REH and SEM leukemia cell lines
MLL-fusion proteins are potent inducers of cancer in hematopoietic cells, where they are known to cause changes in global gene expression. How MLL-fusion proteins interact with the genome has not been established, so we have limited understanding of the pathway by which these proteins generate aber...
ORGANISM(S): Homo sapiens 
2008-12-14 | E-GEOD-13313 | biostudies-arrayexpress
UnknownFirst-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer.
Not available
S-EPMC5648176 | biostudies-literature
GenomicsSetDB1 Contributes to Repression of Genes Encoding Developmental Regulators and Maintenance of ES Cell State
Transcription factors that play key roles in regulating embryonic stem (ES) cell state have been identified, but the chromatin regulators that help maintain ES cells are less well understood. A high-throughput shRNA screen was used to identify novel chromatin regulators that influence ES cell state...
ORGANISM(S): Mus musculus 
2009-11-01 | E-GEOD-18371 | biostudies-arrayexpress
GenomicsChromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells (ChIP-seq)
Knowledge of both the global chromatin structure and the gene expression programs of human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells should provide a robust means to assess whether the genomes of these cells have similar pluripotent states. Recent studies have suggested tha...
ORGANISM(S): Homo sapiens 
2010-08-09 | E-GEOD-23455 | biostudies-arrayexpress
GenomicsChromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells
This SuperSeries is composed of the following subset Series: GSE23402: Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells (Affymetrix) GSE23455: Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells ...
ORGANISM(S): Homo sapiens 
2010-08-08 | E-GEOD-22499 | biostudies-arrayexpress
GenomicsDerivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs invariably exhibit signs of X chromosome inactivation (XCI) and are considered developmentally more advanced than their murine counterparts. W...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-21141 | biostudies-arrayexpress
TranscriptomicsP24_STVI_colorectal_cancer_MIR
Focal and temporal tumor heterogeneity can represent a major challenge for biology-guided therapies. This study proposes to investigative molecular discrepancies between primary colorectal cancer samples and matched metastases
ORGANISM(S): Homo sapiens 
2014-12-30 | E-MTAB-2868 | biostudies-arrayexpress
TranscriptomicsP24_STVI_colorectal_cancer_GEX
Focal and temporal tumor heterogeneity can represent a major challenge for biology-guided therapies. This study proposes to investigative molecular discrepancies between primary colorectal cancer samples and matched metastases
ORGANISM(S): Homo sapiens 
2014-12-30 | E-MTAB-2864 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of Foxp3 in mouse T-cell hybridoma cells
The forkhead transcription factor Foxp3 is essential for the development of CD4+CD25+ regulatory T (Treg) cells and prevention of autoimmunity, but how it controls the Treg gene expression program is not understood. We describe here genome-wide location and expression data that identify Foxp3 targe...
ORGANISM(S): Mus musculus 
2007-01-27 | E-TABM-154 | biostudies-arrayexpress
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