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GenomicsSetDB1 Contributes to Repression of Genes Encoding Developmental Regulators and Maintenance of ES Cell State
Transcription factors that play key roles in regulating embryonic stem (ES) cell state have been identified, but the chromatin regulators that help maintain ES cells are less well understood. A high-throughput shRNA screen was used to identify novel chromatin regulators that influence ES cell state...
ORGANISM(S): Mus musculus 
2009-11-01 | E-GEOD-18371 | biostudies-arrayexpress
TranscriptomicsExpression and ChIP-chip data from REH and SEM leukemia cell lines
MLL-fusion proteins are potent inducers of cancer in hematopoietic cells, where they are known to cause changes in global gene expression. How MLL-fusion proteins interact with the genome has not been established, so we have limited understanding of the pathway by which these proteins generate aber...
ORGANISM(S): Homo sapiens 
2008-12-14 | E-GEOD-13313 | biostudies-arrayexpress
GenomicsChromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells (ChIP-seq)
Knowledge of both the global chromatin structure and the gene expression programs of human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells should provide a robust means to assess whether the genomes of these cells have similar pluripotent states. Recent studies have suggested tha...
ORGANISM(S): Homo sapiens 
2010-08-09 | E-GEOD-23455 | biostudies-arrayexpress
GenomicsChromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells
This SuperSeries is composed of the following subset Series: GSE23402: Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells (Affymetrix) GSE23455: Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells ...
ORGANISM(S): Homo sapiens 
2010-08-08 | E-GEOD-22499 | biostudies-arrayexpress
TranscriptomicsChromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells (Affymetrix)
Knowledge of both the global chromatin structure and the gene expression programs of human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells should provide a robust means to assess whether the genomes of these cells have similar pluripotent states. Recent studies have suggested tha...
ORGANISM(S): Homo sapiens 
2010-08-09 | E-GEOD-23402 | biostudies-arrayexpress
GenomicsEnhancer Decommissioning by LSD1 During Embryonic Stem Cell Differentiation (ChIP-seq)
Transcription factors and chromatin modifiers play important roles in programming and reprogramming of cellular states during development. Much is known about the role of these regulators in gene activation, but relatively little is known about the critical process of enhancer silencing during diff...
ORGANISM(S): Mus musculus 
2012-01-03 | E-GEOD-27841 | biostudies-arrayexpress
GenomicsDerivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs invariably exhibit signs of X chromosome inactivation (XCI) and are considered developmentally more advanced than their murine counterparts. W...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-21141 | biostudies-arrayexpress
UnknownHER2-Overexpressing Breast Cancers Amplify FGFR Signaling upon Acquisition of Resistance to Dual Therapeutic Blockade of HER2.
Not available
S-EPMC5540793 | biostudies-literature
UnknownDelaying surgery for patients with a previous SARS-CoV-2 infection.
Not available
S-EPMC7537063 | biostudies-literature
UnknownElective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.
Not available
S-EPMC8189635 | biostudies-literature
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