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ProteomicsDNA binding reorganizes the intrinsically disordered C-terminal region of PSC in Drosophila PRC1
Polycomb Group (PcG) proteins regulate gene expression by modifying chromatin. A key PcG complex, PRC1, has two activities: a ubiquitin ligase activity for histone H2A, and a chromatin compacting/nucleosome bridging activity that can inhibit transcription and chromatin remodeling. In Drosophila, the...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2020-05-15 | MSV000085418 | MassIVE
GenomicsPolycomb Group proteins are retained at specific sites on chromatin in mitosis
Epigenetic regulation of gene expression, including by Polycomb Group (PcG) proteins, may depend on heritable chromatin states but how these states can be propagated through mitosis is unclear. Using immunofluorescence and biochemical fractionation, we find PcG proteins associated with mitotic chrom...
ORGANISM(S): Drosophila melanogaster 
2013-01-04 | E-GEOD-38166 | biostudies-arrayexpress
ProteomicsChemical footprinting of Polyhomeotic-proximal1289-1577
The Polycomb protein Polyhomeotic (Ph) is implicated in organizing chromatin to regulate gene expression. This activity depends on the sterile alpha motif in Ph, which can form helical polymers. This polymerization activity is believed to create macromolecular assemblies of Polycomb proteins and chr...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2020-07-10 | MSV000085717 | MassIVE
ProteomicsAssociation of Drosophila Polyhomeotic (Ph) and Ph-PHC3 chimeras with PRC1 components in human cells
To determine if ectopically expressed Venus-tagged Polyhomeotic/PHC3 proteins assemble into PRC1 in human cells, we carried out immunoprecipitations with anti-GFP resin followed by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD060324 | Pride
Human flp-in t-rex 293 Co-immunoprecipitation Prc1 Lc-ms/ms 
GenomicsGenome wide analysis of binding of Polyhomeotic and polymerization defective Polyhomeotic in Drosophila S2 cells
To understand the role of the conserved Sterile Alpha Motif of the Polycomb Group protein Polyhomeotic, the genome wide distribution of wild type and polymerization defective Polyhomeotic containing mutations in the SAM domain was determined by ChIP-SEQ. ChIP-seq Identification of polyhomeotic wild ...
ORGANISM(S): Drosophila melanogaster 
2016-03-08 | E-GEOD-60686 | biostudies-arrayexpress
UnknownAcute rehabilitation following traumatic anterior shoulder dislocation (ARTISAN): pragmatic, multicentre, randomised controlled trial.
Not available
S-EPMC10792684 | biostudies-literature
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