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GenomicsPCGF Homologs and RYBP Define Functionally Distinct PRC1 Family Complexes
The heterogeneous nature of mammalian PRC1 complexes has hindered our understanding of their biological functions. Here, we present a comprehensive proteomic and genomic analysis that uncovered six major groups of PRC1 complexes each containing a distinct PCGF subunit, a RING1A/B ubiquitin ligase, a...
ORGANISM(S): Homo sapiens 
2012-02-09 | E-GEOD-34774 | biostudies-arrayexpress
ProteomicsDNA binding reorganizes the intrinsically disordered C-terminal region of PSC in Drosophila PRC1
Polycomb Group (PcG) proteins regulate gene expression by modifying chromatin. A key PcG complex, PRC1, has two activities: a ubiquitin ligase activity for histone H2A, and a chromatin compacting/nucleosome bridging activity that can inhibit transcription and chromatin remodeling. In Drosophila, the...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2020-05-15 | MSV000085418 | MassIVE
ProteomicsPRC1 phosphorylation by CDK1 and PLK1
This work study the effects of PRC1 phosphorylation by CDK1 and PLK1.
ORGANISM(S): Homo sapiens (Human) 
2024-11-01 | PXD055933 | Pride
Prc1 Cdk1 Plk1 
TranscriptomicsPRC1 coordinates timing of sexual differentiation of female primordial germ cells
In mammals, sex differentiation of primordial germ cells (PGCs) is determined by extrinsic cues from the environment1. In female PGCs, expression of Stimulated by retinoic acid 8 (Stra8) and meiosis are induced in response to retinoic acid (RA) provided by the mesonephroi2-4. Given the widespread ro...
ORGANISM(S): Mus musculus 
2013-03-14 | E-GEOD-42782 | biostudies-arrayexpress
TranscriptomicsPRC1 coordinates timing of sexual differentiation of female primordial germ cells (RNA-Seq)
In mammals, sex differentiation of primordial germ cells (PGCs) is determined by extrinsic cues from the environment1. In female PGCs, expression of Stimulated by retinoic acid 8 (Stra8) and meiosis are induced in response to retinoic acid (RA) provided by the mesonephroi2-4. Given the widespread ro...
ORGANISM(S): Mus musculus 
2013-03-14 | E-GEOD-42852 | biostudies-arrayexpress
GenomicsKAP1(TRIM28/TIF1beta) represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1(Ring1b/Rnf2) and derepresses pluripotency-associated genes (ChIP-seq)
Embryonic stem (ES) cells express pluripotency-associated genes and repress differentiation-inducible genes. The activities of these genes are coordinately reversed during differentiation. The changes in the transcriptome upon conditional KAP1 knockout in ES cells overlapped with the changes durin...
ORGANISM(S): Mus musculus 
2014-07-29 | E-GEOD-56628 | biostudies-arrayexpress
ProteomicsPRC1-CBX8 chromatin crosslinking
XL-MS to identify interaction sites of PRC1-CBX8 with chromatin
ORGANISM(S): Homo sapiens (Human) 
2024-12-30 | PXD039589 | Pride
Cbx8 Polycomb Prc1 Chromatin 
TranscriptomicsKAP1(TRIM28/TIF1beta) represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1(Ring1b/Rnf2) and derepresses pluripotency-associated genes (expression)
Embryonic stem (ES) cells express pluripotency-associated genes and repress differentiation-inducible genes. The activities of these genes are coordinately reversed during differentiation. The changes in the transcriptome upon conditional KAP1 knockout in ES cells overlapped with the changes durin...
ORGANISM(S): Mus musculus 
2014-05-09 | E-GEOD-56626 | biostudies-arrayexpress
GenomicsAUTS2 confers transcriptional activation to PRC1 in the CNS (ChIP-Seq)
Naturally occurring variations of Polycomb Repressive Complex 1 (PRC1) comprise a core assembly of Polycomb group proteins and additional factors that include, surprisingly, Autism Susceptibility Candidate 2 (AUTS2). While AUTS2 is often disrupted in patients with neuronal disorders, the underlying ...
ORGANISM(S): Mus musculus 
2014-12-18 | E-GEOD-60409 | biostudies-arrayexpress
GenomicsDirect Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors (ChIP-Seq)
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study, we show that Bmi1, a core component of Polycomb Repressive Complex 1 (PRC1), binds direct...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-33653 | biostudies-arrayexpress
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