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PRC1 phosphorylation by CDK1 and PLK1

ABSTRACT: This work study the effects of PRC1 phosphorylation by CDK1 and PLK1.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Wei Ming Lim

LAB HEAD: Thomas Surrey

PROVIDER: PXD055933 | Pride | 2024-11-01

REPOSITORIES: Pride

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			Action	DRS
	2020MA007_WELI_001_01_mixV2_30pto.msf	Msf
	2020MA007_WELI_001_01_mixV2_30pto.raw	Raw
	2020MA007_WELI_002_01_mixV2_30pto.msf	Msf
	2020MA007_WELI_002_01_mixV2_30pto.raw	Raw
	2020MA007_WELI_003_01_mixV2_30pto.msf	Msf

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Publications

Regulation of minimal spindle midzone organization by mitotic kinases.

Lim Wei Ming WM Chew Wei-Xiang WX Esposito Verza Arianna A Pesenti Marion M Musacchio Andrea A Surrey Thomas T

Nature communications 20241029 1

During cell division, the microtubule cytoskeleton undergoes dramatic cell cycle-driven reorganizations of its architecture. Coordinated by changes in the phosphorylation patterns of a multitude of microtubule associated proteins, the mitotic spindle first self-assembles to capture the chromosomes and then reorganizes in anaphase as the chromosomes are segregated. A key protein for this reorganization is PRC1 which is differentially phosphorylated by the mitotic kinases CDK1 and PLK1. How the ph ...[more]

PMID: 39472429

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