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ProteomicsIdentification of CDK1 substrates in mitosis by quantitative phosphoproteomics
Cyclin-dependent kinase 1 (Cdk1) is an essential regulator of many mitotic processes including the reorganization of the cytoskeleton, chromosome segregation, and formation and separation of daughter cells. Deregulation of Cdk1 activity results in defects in these processes. Although the role of Cdk...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-24 | MSV000079528 | MassIVE
TranscriptomicsRegulation of S-phase transcription factors by Cdk1
Analysis of gene expression across the cell cycle from wild type cells, and cells expressing alleles of Yox1, Yhp1, Hcm1, and Tos4 that cannot be phosphorylated by Cdk1. Expression of S-phase and M/G1 transcripts are downregulated when phosphorylation of these factors is blocked, demonstrating that ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-10 | E-GEOD-55121 | biostudies-arrayexpress
TranscriptomicsRNA-seq of cardiac-specific Cdk1 knockout mice at 3 weeks after experimental myocardial infarction
Biological Relevance and Intent of the Experiment: The objective of this study is to elucidate the role of Cdk1 in cardiac function, specifically its contribution to cardiomyocyte proliferation and response to injury. Using a heart-specific Cdk1 knockout mouse model, we investigate the molecular and...
ORGANISM(S): Mus musculus domesticus 
2024-12-02 | E-MTAB-14508 | biostudies-arrayexpress
TranscriptomicsRNA-seq of cardiac-specific Cdk1 knockout mice at 4 days after experimental myocardial infarction
Biological Relevance and Intent of the Experiment: The objective of this study is to elucidate the role of Cdk1 in cardiac function, specifically its contribution to cardiomyocyte (CM) proliferation and response to injury. Using a heart-specific Cdk1 knockout mouse model, we investigate the molecula...
ORGANISM(S): Mus musculus domesticus 
2024-10-31 | E-MTAB-14505 | biostudies-arrayexpress
ProteomicsCyclin A and Cks1 promote kinase consensus switching to non-proline directed CDK1 phosphorylation
Ordered protein phosphorylation by CDKs is a key mechanism for regulating the cell cycle. How temporal order is enforced in mammalian cells remains unclear. Using a fixed cell kinase assay and phosphoproteomics, we studied how CDK1 activity and non-catalytic CDK1 subunits contribute to the choice of...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD034098 | Pride
Cell cycle Cdk1 Kinase Phosphoproteomics 
ProteomicsPRC1 phosphorylation by CDK1 and PLK1
This work study the effects of PRC1 phosphorylation by CDK1 and PLK1.
ORGANISM(S): Homo sapiens (Human) 
2024-11-01 | PXD055933 | Pride
Prc1 Cdk1 Plk1 
ProteomicsProximity biotinylation of CDK1 associated proteins in U2OS cells
BirA ligase tagged CDK1 and BirA alone were expressed in U2OS cells. Proximal proteins to CDK1 were labelled by incubating cells with Biotin for 24 hours and biotinylated proteins extracted using Streptavidin pulldown.
ORGANISM(S): Homo sapiens (Human) 
2021-05-12 | PXD024796 | Pride
Human Lc-msms Proximity biotinylation Cdk1 
GenomicsEffect of Cell cycle regulator CDK1 on Cell Differentiation (RNA-IP CDK1 inh KD)
Effect of Cell cycle regulator CDK1 on Cell Differentiation (RNA-IP CDK1 inh KD)
PRJNA541529 | ENA
ProteomicsIdentification of CDK1 phosphorylation of TFCP2L1 from murine embryonic stem cells and bladder cancer cells
Molecular programs involved in embryogenesis are frequently upregulated in oncogenic dedifferentiation and metastasis. However, their precise roles and regulatory mechanisms remain elusive. Here, we showed that CDK1 phosphorylation of TFCP2L1, a pluripotency-associated transcription factor, orches...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2019-11-08 | PXD015635 | Pride
Pluripotency Cdk1 Stemness features Embryonic stem-cell Bladder cancer 
ProteomicsThe role of Cdk1-cyclin B in G1/S transition revealed by chemical genetic inhibition of Cdc7
Entry of mammalian cells into DNA synthesis (S-phase) represents a key event in cell division. According to the current cell cycle models, the Cdc7 kinase represents the essential and rate-limiting trigger of DNA replication, acting together with the cyclin-dependent kinase Cdk2. Using chemical gene...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-11 | PXD025625 | Pride
Cdk1-cyclinb G1/s transition Cdc7 Dna replication 
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