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TranscriptomicsRNAi knock down of CDC7 in human IMR90 primary diploid fibroblasts derived from embryonic lung tissue
Transcriptional profiling of siRNA-mediated inhibition of CDC7 in IMR90 primary diploid fibroblasts derived from embryonic lung tissue.
ORGANISM(S): Homo sapiens 
2010-09-03 | E-MEXP-2115 | biostudies-arrayexpress
ProteomicsThe role of Cdk1-cyclin B in G1/S transition revealed by chemical genetic inhibition of Cdc7
Entry of mammalian cells into DNA synthesis (S-phase) represents a key event in cell division. According to the current cell cycle models, the Cdc7 kinase represents the essential and rate-limiting trigger of DNA replication, acting together with the cyclin-dependent kinase Cdk2. Using chemical gene...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-11 | PXD025625 | Pride
Cdk1-cyclinb G1/s transition Cdc7 Dna replication 
GenomicsGenome-wide CRISPR-Cas9 knockout screen in MCF10A with ATP-competitive inhibition of CDC7 (XL-413)
The coordinated activation of DNA replication origins is important for efficient DNA synthesis and genome stability. S-phase cyclin dependent kinases (CDKs) together with CDC7 kinase, are essential to origin activation by converting the pre-replicative complex into a fully active helicase. To identi...
ORGANISM(S): Homo sapiens 
2026-09-30 | E-MTAB-17434 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human breast epithelial cell line MCF10A treated for 8 days with the CDC7 inhibitors XL413, TAK-931 against DMSO-treated controls
CDC7 is a serine-threonine kinase, which has an important role in the activation of replication origins in the S-phase. CDC7 is also a potential molecular target for the development of anticancer drugs. Multiple studies have shown that different cell lines have a wide range of sensitivity to CDC7 i...
ORGANISM(S): Homo sapiens 
2024-05-14 | E-MTAB-13179 | biostudies-arrayexpress
GenomicsThe role of CDC7 in Melanoma cancer growth and progression
The role of CDC7 in Melanoma cancer growth and progression
PRJNA665990 | ENA
GenomicsLocalization of Cdc7 Protein Kinase During DNA Replication in Saccharomyces cerevisiae
Localization of Cdc7 Protein Kinase During DNA Replication in Saccharomyces cerevisiae
PRJNA407733 | ENA
UnknownCharacterization of a Drosophila ortholog of the Cdc7 kinase: a role for Cdc7 in endoreplication independent of Chiffon.
Not available
S-EPMC4340381 | biostudies-literature
GenomicsDBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.
DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.
PRJNA1046531 | ENA
TranscriptomicsThe role of CDC7 in Melanoma cancer growth and progression
Disruptor of Cell Division Cycle 7 (CDC7) expression is elevated in many cancer types including melanoma. Therefore, we analyzed the role of CDC7 in melanoma. Pharmacological inhibition of CDC7 expression in Melanoma cancer cell lines resulted in decreased proliferation, and increased cell death.
ORGANISM(S): Homo sapiens 
2022-08-10 | GSE158621 | GEO
ProteomicsThe structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer
The controlled assembly of replication forks is critical for genome stability. The Dbf4-dependent Cdc7 kinase (DDK) initiates replisome assembly by phosphorylating the MCM2-7 replicative helicase at the N-terminal tails of Mcm2, Mcm4 and Mcm6. At present, it remains poorly understood how DDK docks o...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2022-05-31 | PXD031315 | Pride
Cryo-em Ddk Yeast S-phase Dbf4 Molecular dynamics Helicase Origins Cdc7 Helicase activation Kinase Mcm2-7 Dna replication 
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