Sort   by:  
 Page size 
MetabolomicsFirefly genomes illuminate parallel origins of bioluminescence in beetles
Fireflies and their luminous courtships have inspired centuries of scientific study. Today firefly luciferase is widely used in biotechnology, but the evolutionary origin of bioluminescence within beetles remains unclear. To shed light on this long-standing question, we sequenced the genomes of two ...
2018-09-14 | MTBLS698 | MetaboLights
MetabolomicsMetabolome data to annotate metabolite origins
Not available
ORGANISM(S): Homo sapiens 
ST001268 | MetabolomicsWorkbench
GenomicsUnraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs
Short nascent strands purification coupled to next-generation sequencing allowed us to identify replication origins on human genome in an extensive way, by mapping replication origins in 4 different cell types, IMR-90 fibroblasts, hESC H9 cells, iPSC Th Cl-4 cells and HeLa cells. We demonstrated the...
ORGANISM(S): Homo sapiens 
2012-07-01 | E-GEOD-37757 | biostudies-arrayexpress
TranscriptomicsMapping origins of replication in Arabidopsis thaliana: Examination of BrdU labeled DNA and unlabeled DNA in one cell type
Genomic integrity requires faithful chromosome duplication. Origins of replication are the genomic sites where DNA replication initiates in every cell cycle. There are multiple origins scattered throughout the eukaryotic genome whose genome-wide identification has been a hard challenge, especially i...
ORGANISM(S): Arabidopsis thaliana 
2011-11-06 | E-GEOD-21781 | biostudies-arrayexpress
MetabolomicsMetabolomic investigations on Nesterenkonia flava from different origins revealed significant intraspecies differences between marine and terrestrial actinomycetes
Not available
ORGANISM(S): Nesterenkonia flava 
ST000875 | MetabolomicsWorkbench
TranscriptomicsRif1 regulates initiation timing of late replication origins throughout the S. cerevisiae genome [ChIP-Seq]
Chromosomal DNA replication involves the coordinated activity of hundreds to thousands of replication origins. Individual replication origins are subject to epigenetic regulation of their activity during S-phase, resulting in differential efficiencies and timings of replication initiation during S-...
ORGANISM(S): Saccharomyces cerevisiae 
2014-06-01 | E-GEOD-55155 | biostudies-arrayexpress
GenomicsORC precisely positions nucleosomes at origins of replication
The budding yeast genome is marked by 250-350 origins of DNA replication. These origins are bound by the origin recognition complex (ORC) throughout the cell cycle. ORC has known DNA binding sequence preferences which, though necessary for binding, are not sufficient to fully specify a genomic locus...
ORGANISM(S): Saccharomyces cerevisiae 
2010-03-19 | E-GEOD-16926 | biostudies-arrayexpress
TranscriptomicsRif1 regulates initiation timing of late replication origins throughout the S. cerevisiae genome [array]
Chromosomal DNA replication involves the coordinated activity of hundreds to thousands of replication origins. Individual replication origins are subject to epigenetic regulation of their activity during S-phase, resulting in differential efficiencies and timings of replication initiation during S-...
ORGANISM(S): Saccharomyces cerevisiae 
2014-06-01 | E-GEOD-55130 | biostudies-arrayexpress
TranscriptomicsHigh resolution mapping of DNA replication origins in human genome
Because of the lack of information, regulation of DNA replication initiation in mammals is still poorly understood. In order to identify general rules, we have mapped replication origins along 1% of the human genome in HeLa cells. We found large gene-poor regions lacking origin and G+C rich regions ...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-10217 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of S. pombe co-overexpressing DNA synthesis initiation factors cdc18 (cdc6) and cdt1 to investigate gene copy number increases
During S-phase of the eukaryotic cell cycle, controls exist to ensure that replication origins fire only once and become inactivated after traverse of a replication fork. Failure of these controls results in local amplification of the genome which can lead to gene copy increases important for both ...
ORGANISM(S): Schizosaccharomyces pombe 
2010-08-13 | E-MTAB-139 | biostudies-arrayexpress
Sort   by:  
 Page size