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ProteomicsHuman DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
To date few DDK substrates other than the MCM helicase have been identified, and none are implicated in fork protection or restart. Here we searched for such factors, using SILAC and quantitative mass spectrometry to identify the DDK phosphoproteome during fork stalling.
ORGANISM(S): Homo sapiens (Human) 
2021-06-29 | PXD014399 | Pride
Lc-ms/ms Chemical genetics Cdc7 Ddk Stalled forks Analogue-sesitive Phosphoproteomics Replication 
ProteomicsDbf4-dependent kinase (DDK) and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosis
DNA repair by homologous recombination is under stringent cell cycle control. This includes the last step of the reaction, disentanglement of DNA joint molecules (JMs). Previous work has established that JMs resolving nucleases are activated specifically at the onset of mitosis. In case of budding y...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-01-21 | PXD005356 | Pride
Ddk Yeast Dna repair 
TranscriptomicsOrigin-Dependent DNA Replication in vitro: Insights into DDK and S-CDK function and Replisome Assembly
Initiation of eukaryotic DNA replication requires temporal separation of helicase loading from helicase activation and replisome assembly. Using an in vitro assay for eukaryotic origin-dependent replication initiation, we investigated the control of these events. After helicase loading, we found t...
ORGANISM(S): Saccharomyces cerevisiae 
2011-07-21 | E-GEOD-29646 | biostudies-arrayexpress
UnknownThe potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds.
Not available
S-EPMC4239038 | biostudies-literature
GenomicsLimonoid DDK restores mitochondrial redox homeostasis to alleviate metabolic dysfunction-associated steatohepatitis via promoting SDHA deacetylation and SDH complex activity
Limonoid DDK restores mitochondrial redox homeostasis to alleviate metabolic dysfunction-associated steatohepatitis via promoting SDHA deacetylation and SDH complex activity
PRJNA1438622 | ENA
UnknownRad51-mediated replication of damaged templates relies on monoSUMOylated DDK kinase.
Not available
S-EPMC9072374 | biostudies-literature
TranscriptomicsLimonoid DDK restores mitochondrial redox homeostasis to alleviate metabolic dysfunction-associated steatohepatitis via promoting SDHA deacetylation and SDH complex activity
Mitochondrial dysfunction and redox imbalance are key drivers of metabolic dysfunction-associated steatohepatitis (MASH), yet therapeutic strategies targeting mitochondrial respiratory integrity remain limited. We identified succinate dehydrogenase subunit A (SDHA) as a direct functional target of t...
ORGANISM(S): Mus musculus 
2026-05-01 | GSE325089 | GEO
UnknownThe unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome.
Not available
S-EPMC2723760 | biostudies-literature
Genomics
CK absorption in Korean Volunteers from DDK-401
PRJNA873242 | ENA
UnknownCDC7 kinase (DDK) inhibition disrupts DNA replication leading to mitotic catastrophe in Ewing sarcoma.
Not available
S-EPMC8882187 | biostudies-literature
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