Sort   by:  
 Page size 
ProteomicsMudPIT analysis of the Dbf4/Chiffon and Gcn5 complex in Drosophila
During evolution, there has been an expansion in the diversity of histone acetyltransferase Gcn5-containing complexes. All Gcn5 complexes share Sgf29 and Ada3 subunits, which together with their respective Ada2 homolog, enable nucleosomal HAT activity. In metazoans, including Drosophila, there are t...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2017-12-07 | MSV000081791 | MassIVE
ProteomicsThe structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer
The controlled assembly of replication forks is critical for genome stability. The Dbf4-dependent Cdc7 kinase (DDK) initiates replisome assembly by phosphorylating the MCM2-7 replicative helicase at the N-terminal tails of Mcm2, Mcm4 and Mcm6. At present, it remains poorly understood how DDK docks o...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2022-05-31 | PXD031315 | Pride
Cryo-em Ddk Yeast S-phase Dbf4 Molecular dynamics Helicase Origins Cdc7 Helicase activation Kinase Mcm2-7 Dna replication 
GenomicsDBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.
DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.
PRJNA1046531 | ENA
GenomicsSevere congenital neutropenia with syndromic features in a patient with homozygous hypomorphic DBF4 mutation
Severe congenital neutropenia with syndromic features in a patient with homozygous hypomorphic DBF4 mutation
PRJNA673425 | ENA
TranscriptomicsKinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment
Centromeres play several important roles in ensuring proper chromosome segregation. Not only do they promote kinetochore assembly for microtubule attachment, but they also support robust sister chromatid cohesion at pericentromeres and facilitate replication of centromeric DNA early in S phase. Howe...
ORGANISM(S): Saccharomyces cerevisiae 
2013-06-06 | E-GEOD-41982 | biostudies-arrayexpress
OtherDBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.
In eukaryotes, CDC7 kinase is crucial for DNA replication initiation and has been involved in fork processing and replication stress response. Human CDC7 requires the binding of either one of two regulatory subunits, DBF4 and DRF1, for its activity. However, it is unclear whether the two regulatory ...
ORGANISM(S): Homo sapiens 
2024-03-28 | GSE248981 | GEO
TranscriptomicsSevere congenital neutropenia with syndromic features in a patient with homozygous hypomorphic DBF4 mutation
Accurate and efficient DNA synthesis is an essential function of replicating cells. Mutations in replisome components lead to a number of syndromic diseases including immunodeficiencies. Dumbbell former 4 (DBF4) is the regulatory subunit of the DBF4-dependent kinase (DDK) which is essential for the ...
ORGANISM(S): Homo sapiens 
2022-06-10 | GSE160517 | GEO
OtherDbf4 recruitment by forkhead transcription factors defines an upstream rate-limiting step in determining replication origin firing
Initiation of eukaryotic chromosome replication follows a spatiotemporal program. Current model suggests that replication origins compete for a limited pool of initiation factors. However, it remains to be answered how these limiting factors are preferentially recruited to early origins. Here, we re...
ORGANISM(S): Saccharomyces cerevisiae 
2018-01-19 | GSE103073 | GEO
UnknownSaccharomyces cerevisiae Dbf4 has unique fold necessary for interaction with Rad53 kinase.
Not available
S-EPMC3268399 | biostudies-literature
UnknownDbf4: the whole is greater than the sum of its parts.
Not available
S-EPMC3674083 | biostudies-literature
Sort   by:  
 Page size