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ProteomicsPRC1-CBX8 chromatin crosslinking
XL-MS to identify interaction sites of PRC1-CBX8 with chromatin
ORGANISM(S): Homo sapiens (Human) 
2024-12-30 | PXD039589 | Pride
Cbx8 Polycomb Prc1 Chromatin 
TranscriptomicsHelin M.musculus Identification of genes repressed by CBX8 and BMI1
The polycomb group proteins form large repressive complexes. It has recently become evident, via ChIP on chip analysis, that the polycomb complexes, PRC1 and PRC2, target a large number of genes (Boyer et al., 2006; Bracken et al., 2006; Tolhuis et al., 2006), which are involved in cell fate decisio...
ORGANISM(S): Mus musculus 
2007-03-05 | E-MEXP-793 | biostudies-arrayexpress
GenomicsCBX8 KO and WT re-expression RNA-seq
CBX8 KO and WT re-expression RNA-seq
PRJNA509611 | ENA
ProteomicsRNF2_PCGF4_CBX8 crosslinked with BS3
Recombinant PRC1 complex consisting of RNF2, PCGF4 and CBX8 was crosslinked with BS3 to identify complex structure
ORGANISM(S): Homo sapiens (Human) 
2024-12-30 | PXD049094 | Pride
Xl-ms Prc1 Cbx8 Polycomb 
GenomicsTranscriptome of CBX7 and CBX8 overexpressing CD34+ HSPCs
Transcriptome of CBX7 and CBX8 overexpressing CD34+ HSPCs
PRJEB22831 | ENA
GenomicsA Cbx8-containing Polycomb complex facilitates gene activation during ES cell differentiation [ChIP-Seq]
Polycomb proteins play an essential role in maintaining the repression of developmental genes in self-renewing embryonic stem cells. The exact mechanism allowing the derepression of polycomb target genes during cell differentiation remains unclear. Here, we show that several differentiation genes tr...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-54052 | biostudies-arrayexpress
GenomicsPolycomb Cbx orthologs mediate the balance between Hematopoietic Stem Cell self-renewal and differentiation
By genome-wide ChIP-seq analyses we show that Cbx7 and Cbx8 share ~95% of their targets in bone marrow cells. Cbx7 and Cbx8 have only ~200 targets that are not overlapping between the two proteins. These distinct Cbx7 and Cbx8 targets show reciprocal expression patterns along hematopoietic different...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-36658 | biostudies-arrayexpress
GenomicsREPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR
REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR
PRJNA756978 | ENA
ProteomicsSynthetic lethal combinations targeting PLK1-CBX8-GPX4 axis with BRAF and EGFR inhibition in BRAF V600E colorectal cancer
Metastatic BRAFV600E colorectal cancer (CRC) confers poor prognosis and run into a bottleneck in the current treatment strategies. To identify regulatory pathways independent of the MAPK pathway in BRAFV600E CRC, we performed CRISPR-Cas9 screening, and and find targeting glutathione peroxidase 4 (GP...
ORGANISM(S): Homo Sapiens 
2024-11-25 | PXD058213 |
GenomicsCBX8 promotes LUAD growth and metastasis through transcriptional repression of CDKN2C and SCEL
CBX8 promotes LUAD growth and metastasis through transcriptional repression of CDKN2C and SCEL
PRJNA981976 | ENA
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