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MetabolomicsInhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

BACKGROUND: Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, the 5-year overall survival rate of high-risk disease remai...

2022-11-30 | MTBLS858 | MetaboLights
TranscriptomicsRegulation of the ESC transcriptome by nuclear long non-coding RNAs
We performed poly(A)+ RNA sequencing (Illumina GAIIx) from nuclear and whole cell RNA fractions of mouse AB2.2 embryonic stem cells (ESCs) and neural progenitors (NPCs) differentiated from ESCs. We further transfected AB2.2 ESCs with control antisense oligonucleotides (ASOs), or 2 independent ASOs e...
ORGANISM(S): Mus musculus 
2015-12-01 | E-MTAB-3198 | biostudies-arrayexpress
UnknownComparison of Clinical Trial and Systematic Review Outcomes for the 4 Most Prevalent Eye Diseases.
Not available
S-EPMC5625342 | biostudies-literature
TranscriptomicsNovel biomarkers for distributed stem cells: asymmetric self-renewal associated (ASRA) genes identification by combined cDNA micro-array orthogonal intersection and sparse feature analysis
Biomarkers unique for distributed stem cells (DSCs) have proven elusive. Previous searches for proteins expressed specifically in DSCs were hampered by difficulty obtaining pure DSCs and challenges to successfully mining complex molecular expression data. To identify novel candidates for DSC bioma...
ORGANISM(S): Mus musculus 
2014-06-30 | E-GEOD-40183 | biostudies-arrayexpress
TranscriptomicsComparison of Environmental and Genetic models of ADHD
ADHD is the most common neurobehavioral disorder in school-aged children. In addition to genetic factors, environmental influences or gene x environmental interactions also play an important role in ADHD. One example of a well studied environmental risk factor for ADHD is exposure to polychlorinated...
ORGANISM(S): Rattus norvegicus 
2008-11-20 | E-GEOD-12457 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiles in primary cutaneous melanoma are associated with clinically significant pathologic features
We investigated whether methylation in primary melanomas is associated with tumor pathologic features or defines subgroups of primary melanomas 47 primary cutaneous melanomas were analyzed using the Illumina GoldenGate Cancer Panel I methylation array
ORGANISM(S): Homo sapiens 
2015-06-15 | E-GEOD-54623 | biostudies-arrayexpress
UnknownMinimal manifestation status and prednisone withdrawal in the MGTX trial.
Not available
S-EPMC7455358 | biostudies-literature
UnknownRelationship Between Age and Pathology With Treatment of Pediatric and Adolescent Discoid Lateral Meniscus: A Report From the SCORE Multicenter Database.
Not available
S-EPMC10623608 | biostudies-literature
GenomicsNational Eye Institute Glaucoma Human Genetics Collaboration (NEIGHBOR) Consortium Glaucoma Genome-Wide Association Study

This is a case-control study of primary open angle glaucoma (POAG). POAG is an intraocular pressure (IOP) related progressive optic neuropathy that ultimately leads to blindness. For this study we have formed a collaborative consortium contributing 2170 POAG cases and 2347 controls with a unified...

phs000238.v1.p1 | EGA
GenomicsAlzheimer's Disease Sequencing Project (ADSP)

The overarching goals of the ADSP are to: (1) identify new genomic variants contributing to increased risk of developing AD, (2) identify new genomic variants contributing to protection against developing AD, and (3) provide insight as to why individuals with known risk factor variants escape fro...

phs000572.v1.p1 | EGA
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