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TranscriptomicsTranscription profiling of mammary tissues from mouse model of breast cancer conditionally expressing Etv6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation
For the largest class of human tumors, those of epithelial origin, little is known about their initiating genetic hits or cells of origin. Whether tissue stem cells or more committed progenitors are targets for transformation is also uncertain. Experience in hematopoietic malignancies and sarcomas ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9343 | biostudies-arrayexpress
TranscriptomicsRNAseq of human B-ALL cell lines following RUNX1 or CBFb knock-down
Five B-ALL cell lines representing major genetic subtypes were transfected with shRNAs targeting components of the core binding factor (CBF) complex. Five days after transfection, viable, shRNA-expressing cells were sorted and RNA was harvested. RNAseq was performed and knock-down samples compared t...
ORGANISM(S): Homo sapiens 
2022-04-10 | E-MTAB-10329 | biostudies-arrayexpress
TranscriptomicsRNA-seq following shRNA-mediated knock-down of ETV6-RUNX1 in the B-ALL cell line Reh
Stable derivatives of the Reh cell line carrying inducible shRNAs were generated by transducing with lentivirus harbouring the pTRIPZ vector and enabling doxycycline-inducible expression of shRNAs together with an RFP reporter. Two independent lines carrying different shRNAs targeting ETV6 or a vect...
ORGANISM(S): Homo sapiens 
2022-04-10 | E-MTAB-10308 | biostudies-arrayexpress
UnknownA randomized, phase II, biomarker-selected study comparing erlotinib to erlotinib intercalated with chemotherapy in first-line therapy for advanced non-small-cell lung cancer.
Not available
S-EPMC3179254 | biostudies-literature
GenomicsDeep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer
Our understanding of genomic heterogeneity in lung cancer is largely based on the analysis of early-stage surgical specimens. Here we used endoscopic sampling of paired primary and intrathoracic metastatic tumors from 11 lung cancer patients to map genomic heterogeneity inoperable lung cancer with d...
EGAS00001003830 | EGA
GenomicsNational Eye Institute Glaucoma Human Genetics Collaboration (NEIGHBOR) Consortium Glaucoma Genome-Wide Association Study

This is a case-control study of primary open angle glaucoma (POAG). POAG is an intraocular pressure (IOP) related progressive optic neuropathy that ultimately leads to blindness. For this study we have formed a collaborative consortium contributing 2170 POAG cases and 2347 controls with a unified...

phs000238.v1.p1 | EGA
Genomics5b85420b-44cf-4d0a-9fa8-4930e698bc25 - samples
Deep WGS (germline and 2-5 tumour regions) was performed on 20 patients: 13 lung adenocarcinoma, 5 squamous cell carcinoma, 2 small-cell lung cancers. A total of 68 BAM files are provided, where tumours were sequenced to 60x or 150x depth.
EGAD00001005287 | EGA
GenomicsGarvan Institute of Medical Research
Data Access Committee EGAC00001001300
EGAC00001001300 | EGA
ProteomicsMitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer
TMT-MS of whole cell lysate collected from 22Rv1 castration-resistant prostate cancer cells treated with 5 µM JG-98 for 4 hours.
ORGANISM(S): Homo Sapiens (human) 
2023-04-25 | PXD038684 | JPOST Repository
ProteomicsDIA of Gasdermin-D knockout and cuprizone treated mouse brain tissue
Data-independent acquisition (DIA) of four replicates of mouse brain tissue lysate for each of the four conditions Gasdermin-D WT, Gasdermin-D KO, Gasdermin-D WT treated with cuprizone, and Gasdermin-D KO treated with cuprizone.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-02-02 | MSV000091185 | MassIVE
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