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TranscriptomicsERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation
To investigate the role of the transcription factor ERG in hematopoiesis we generated Erg heterozygous knockout and conditional Erg knockout mice. We found that several hematopoietic cell types were decreased in these mice. To define Erg downstream target genes in hematopoietic stem cells, we sorted...
ORGANISM(S): Mus musculus 
2015-09-21 | E-GEOD-69873 | biostudies-arrayexpress
ProteomicsRole of SurA, BamB, BamC and HlpA for shaping the outer membrane protein composition of Pseudomonas aeruginosa
Pseudomonas aeruginosa (Pa) is one of the main causative agents of nosocomial infections and the spread of multidrug-resistant strains is rising. The outer membrane composition of Pa restricts antibiotic entry and determines virulence. For efficient outer membrane protein biogenesis, the BAM complex...
ORGANISM(S): Pseudomonas aeruginosa 
2019-03-12 | PXD011849 | Pride
Hlpa Cell surface molecules Outer membrane protein biogenesis Bamb Bamc Pseudomonas aeruginosa Bacterial infection Sura 
UnknownMolecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
Not available
S-SCDT-10_1038-S44318-025-00679-8 | biostudies-other
ModelsWitting2018 - WormJam-GEM - Whole-genome metabolic reconstructions for Caenorhabditis elegans.
Whole-genome metabolic reconstructions for the model organism Caenorhabditis elegans.
2024-12-21 | MODEL1807230002 | BioModels
MetabolomicsSARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces ...
2021-06-11 | MTBLS2840 | MetaboLights
Genomicsena-DATASET-IPPTS-27-02-2017-14:56:21:344-317 - samples
Exome sequencing for 2 infertile brothers
EGAD00001003193 | EGA
GenomicsA no-stop mutation in MAGEB4 is a possible cause of rare X-linked azoospermia and oligozoospermia in a consanguineous Turkish family
Purpose: The purpose of this study was to identify mutations that cause non-syndromic male infertility using whole exome sequencing of family cases.Methods: We recruited a consanguineous Turkish family comprising nine siblings with male triplets; two of the triplets were infertile as well as one you...
EGAS00001002272 | EGA
GenomicsMAGEB4:X-linked cause of inherited male infertility
Data Access Committee EGAC00001000599
EGAC00001000599 | EGA
UnknownWhole exome sequencing identifies potential candidate genes for spina bifida derived from mouse models.
Not available
S-EPMC8995376 | biostudies-literature
GenomicsC/EBPa is required for self-renewal, lineage priming and maintenance of epigenetic configurations in hematopoietic stem cells
Transcription factors are key regulators of hematopoieticstem cells (HSCs) and act through their ability to bind DNA andimpact on gene transcription. Their functions are interpreted inthe complex landscape of chromatin but current knowledge on howthis is achieved is very limited. C/EBPa is an import...
ORGANISM(S): Mus musculus 
2013-12-01 | E-GEOD-43007 | biostudies-arrayexpress
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