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Purpose: Clinical courses of neuroblastomas (NBs) range from rapid progression with fatal outcome despite intensive multimodality therapies to spontaneous regression. Amplified MYCN oncogene defines a subgroup with poor outcome. However, a substantial number of MYCN single-copy NBs exhibits an aggre...
ORGANISM(S): Homo sapiens 
Purpose: Clinical courses of neuroblastomas (NBs) range from rapid progression with fatal outcome despite intensive multimodality therapies to spontaneous regression. Amplified MYCN oncogene defines a subgroup with poor outcome. However, a substantial number of MYCN single-copy NBs exhibits an aggre...
ORGANISM(S): Homo sapiens 
Aging and chronic sun exposure cause distinct epigenetic changes in human skin
ORGANISM(S): Homo sapiens 
Exercise leads to a rapid change in the profile of gene expression in circulating neutrophils. We hypothesized that miRNA expression in circulating neutrophils would also be affected by brief exercise. Eleven healthy men (19-30 yr old) performed 10 2-min bouts of cycle ergometer exercise intersperse...
ORGANISM(S): Homo sapiens 
Histone modifications are epigenetic marks that play fundamental roles in many biological processes including the control of chromatin-mediated regulation of gene expression. To begin to understand the impact of natural variation on histone methylation levels we generated and quantified large-scale ...
ORGANISM(S): Rattus norvegicus 
Profiling CD34+ BCR-ABL+ cells of CML patients in chronic phase or blast crisis to identify differentially expressed stage-specific genes.
ORGANISM(S): Homo sapiens 
Identification of differentially expressed genes in the blood of chronic phase patients with chronic myeloid leukemia (CML) harboring different bcr-abl transcript variants. All leukemic samples were collected prior to therapy at the time point of the initial diagnosis of CML.
ORGANISM(S): Homo sapiens 
Identification of genes in CML patients with predictive value for their primary cytogenetic outcome to imatinib. All samples analyzed were taken just before the start of imatinib treatment. Leukemic patients were treated second-line with imatinib after failure of an interferon-alpha based therapy (f...
ORGANISM(S): Homo sapiens 
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