Natural variation of histone modification and its impact on gene expression in rat

ABSTRACT: Histone modifications are epigenetic marks that play fundamental roles in many biological processes including the control of chromatin-mediated regulation of gene expression. To begin to understand the impact of natural variation on histone methylation levels we generated and quantified large-scale genome-wide ChIP-seq data in a panel of rat recombinant inbred strains and their parental progenitors. Linkage analysis identified hundreds of cis- and trans-acting loci responsible for quantitative differences in histone trimethyl-lysine levels in left ventricular heart and liver tissues. We assessed the association of histone methylation and gene expression levels by generating deep RNA-seq profiles across the segregating population. Among the main findings, causal modelling of DNA variation t

ORGANISM(S): Rattus norvegicus

SUBMITTER: Oliver Hummel 

PROVIDER: E-MTAB-1102 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress