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TranscriptomicsRNA-Seq from flowers of wildtype Arabidopsis thaliana and DWEORG1 (At3g15590) mutant
As one of the largest protein family in landplants pentatricopeptide repeat (PPR) proteins offer a wide research array. They are mostly involved in the RNA processing steps in Chloroplasts and Mitochondria. Recently it has been shown, that they are not only involved in the RNA processing steps, but ...
ORGANISM(S): Arabidopsis thaliana 
2022-07-13 | E-MTAB-11928 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary osteoblasts treated with estradiol or the pure antagonist ICI 182,780a potent inhibitor of estrogen receptor signaling
Transcriptional profiling of estrogen regulated genes in human primary osteoblasts. The cells were either treated with estradiol (1 nM) or the pure antagonist ICI 182,780 (Faslodex), which acts as a potent inhibitor of estrogen receptor signaling.
ORGANISM(S): Homo sapiens 
2007-08-01 | E-MEXP-1053 | biostudies-arrayexpress
TranscriptomicsmiRseq Analysis of Human Macrophages Co-cultured with MCF-7 Breast Cancer Cells
Tumor-immune cell interactions shape the immune cell phenotype, with microRNAs (miRs) being crucial components of this crosstalk. How they are transferred, and how they affect their target landscape, especially in tumor-associated macrophages (TAMs), is largely unknown. Here we aimed to define miRo...
ORGANISM(S): Homo sapiens 
2019-02-08 | E-MTAB-6885 | biostudies-arrayexpress
TranscriptomicsStudying enhancer activity by FAIRE-STARR-seq in the U2OS-GR and the U2OS-AR cells upon hormone treatment
To quantify functional enhancers, we performed STARR-seq (Self-Transcribing Active Regulatory Region sequencing) in the U2OS-GR and the U2OS-AR cell lines (derived from U2OS ATTC:HTB-96, stably transfected with an expression construct for rat GR or human AR, respectively). U2OS-GR cells were treated...
ORGANISM(S): Homo sapiens 
2021-03-09 | E-MTAB-9614 | biostudies-arrayexpress
TranscriptomicsATAC-seq in the U2OS-AR cell line comparing cells treated for 4 hours with 5 nM R1881 to vehicle (DMSO) control-treated cells
We performed ATAC-seq in the U2OS-AR cell line (derived from U2OS ATTC:HTB-96, stably transfected with an expression construct for human AR), upon androgen (R1881) or vehicle (DMSO) treatment for 4 hours.
ORGANISM(S): Homo sapiens 
2021-03-09 | E-MTAB-9606 | biostudies-arrayexpress
TranscriptomicsRNA-seq in the U2OS-AR cell line to identify genes regulated by the androgen receptor
To identify the genes regulated by the androgen receptor (AR), we performed RNA-seq in the U2OS-AR cell line (derived from U2OS ATTC:HTB-96, stably transfected with an expression construct for human AR), upon androgen (R1881) or vehicle (DMSO) treatment for 24 hours.
ORGANISM(S): Homo sapiens 
2021-03-09 | E-MTAB-9622 | biostudies-arrayexpress
GenomicsAndrogen receptor uses relaxed response element stringency for selective chromatin binding and transcriptional regulation in vivo
We report the in vivo androgen receptor (AR) binding sites in caput epididymis of intact SPARKI and wild-type mice using ChIP-sequencing. SPARKI (specificity affecting androgen receptor knock-in) mouse line has the second zinc finger of AR replaced by that of glucocorticoid receptors. In vivo analys...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-51106 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of H3K27ac, H3K4me1, H3K27me3 and H3K9me3 (ChIP-seq) in U2OS-GR and U2OS-AR cells
We performed ChIP-seq targeting the H3K27ac, H3K4me1, H3K27me3 and H3K9me3 in the U2OS-GR and U2OS-AR cell lines. The cell lines are derived from U2OS ATTC:HTB-96 and stably transfected with an expression construct for either rat GR or human AR, respectively. The U2OS-GR cells were treated with dexa...
ORGANISM(S): Homo sapiens 
2021-03-09 | E-MTAB-9617 | biostudies-arrayexpress
TranscriptomicsGlucocorticoid and androgen receptor profiling (ChIP-seq) in U2OS-GR and U2OS-AR cells upon hormone treatment
We performed ChIP-seq targeting the glucocorticoid receptor (GR) in the U2OS-GR cell line and the androgen receptor (AR) in the U2OS-AR cell line. The cell lines are derived from U2OS ATTC:HTB-96 and stably transfected with an expression construct for either rat GR or human AR, respectively. The U2O...
ORGANISM(S): Homo sapiens 
2021-03-09 | E-MTAB-9616 | biostudies-arrayexpress
UnknownMyeloproliferative neoplasm (MPN) symptom assessment form total symptom score: prospective international assessment of an abbreviated symptom burden scoring system among patients with MPNs.
Not available
S-EPMC4872304 | biostudies-literature
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