Sort   by:  
 Page size 
TranscriptomicsCharacterization of long non-coding RNAs expressed during oocyte-to-embryo transition in mice
Sequencing of polyA RNA fraction from MT oocytes and 1cell embryos.
ORGANISM(S): Mus musculus 
2017-05-21 | E-MTAB-4775 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Mouse erythro-leukaemia cells during differentiation to investigate the influence of Runx1 transcription factor
We investigated the influence of Runx1 transcription factor on gene expression during the differentiation of Mouse Erythro-Leukaemia cells. Cultured cells were induced to differentiate by DMSO. Transcription profiling was done in triplicates, before and after Runx1 knockdown in both induced and non-...
ORGANISM(S): Mus musculus 
2012-06-12 | E-MTAB-1171 | biostudies-arrayexpress
TranscriptomicsA retrotransposon-driven Dicer variant enhances endogenous RNAi in mouse oocytes
Mammals have one Dicer gene required for biogenesis of small RNAs in microRNA (miRNA) and RNA interference (RNAi) pathways. Yet, endogenous RNAi is highly active in oocytes but not in somatic cells. Here, we provide a mechanistical explanation for high RNAi activity in mouse oocytes. The main Dicer ...
ORGANISM(S): Mus musculus 
2013-11-07 | E-GEOD-41207 | biostudies-arrayexpress
TranscriptomicsA new type of pathogenic transcription factor mutation targeting interferon regulatory factor 4 (IRF4) in human lymphoma
We report the characterization of a recurrent somatic mutation c.295T>C (p.C99R) in the Interferon Regulatory Factor 4 (IRF4) gene in human lymphoma in the α3-recognition helix of the IRF4 DNA-binding domain. IRF4-C99R fundamentally alters IRF4 DNA-binding, combining loss-of-binding at canonical IRF...
ORGANISM(S): Mus musculus 
2023-07-21 | E-MTAB-12522 | biostudies-arrayexpress
TranscriptomicsLymphoma-induced regression of high endothelial venules impairs homeostatic lymphocyte trafficking
Lymphoma growth is facilitated by the well-balanced infrastructure of the microenvironment in lymph nodes (LN). LNs undergo rapid expansion during lymphoma progression, often accompanied by excessive blood vessel growth. Here we report that aggressive lymphoma cause severe high endothelial venule (H...
ORGANISM(S): Mus musculus 
2021-10-14 | E-MTAB-10389 | biostudies-arrayexpress
TranscriptomicsPHF3 binds RNA polymerase II via the SPOC domain and regulates transcription of neuronal genes - Targeted SLAM-seq
Tergeted SLAM seq of WT, PHF3 KO and dSPOC, HEK293 cells
ORGANISM(S): Homo sapiens 
2021-09-07 | E-MTAB-7899 | biostudies-arrayexpress
TranscriptomicsThe SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators - TTseq
TTseq of HEK cell lines created by making KO or removing the SPOC domain of PHF3, DIDO1, SHARP, and RBM15 proteins
ORGANISM(S): Homo sapiens 
2023-06-19 | E-MTAB-12359 | biostudies-arrayexpress
TranscriptomicsLocal translational program at the muscle-tendon junction endows domain identity in muscle syncytia - Exercise
Skeletal muscle fibers are large multinucleated cells that form specialized subdomains such as the neuromuscular and myotendinous junctions (MTJ), the latter connecting muscle to tendon and transmitting contractile force. While transcriptional heterogeneity among myonuclei is established, the contri...
ORGANISM(S): Mus musculus 
2026-09-30 | E-MTAB-16306 | biostudies-arrayexpress
TranscriptomicsPHF3 regulates RNA stability through PHD and TLD domains - RNAseq PHD - TLD
Transcription and RNA processing are tightly coupled and precisely coordinated to ensure appropriate levels of mature transcripts. The C-terminal domain (CTD) of RNA polymerase II (Pol II) is phosphorylated differentially during the transcription cycle and serves as a landing pad for a variety of tr...
ORGANISM(S): Homo sapiens 
2025-12-04 | E-MTAB-14530 | biostudies-arrayexpress
TranscriptomicsLocal translational program at the muscle-tendon junction endows domain identity in muscle syncytia - Riboseq
Skeletal muscle fibers are large multinucleated cells that form specialized subdomains such as the neuromuscular and myotendinous junctions (MTJ), the latter connecting muscle to tendon and transmitting contractile force. While transcriptional heterogeneity among myonuclei is established, the contri...
ORGANISM(S): Mus musculus 
2026-09-30 | E-MTAB-16304 | biostudies-arrayexpress
Sort   by:  
 Page size