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ProteomicsPlatelets fuel the inflammasome activation of innate immune cells
Proteomic analysis of cell-free supernatants (Secretome) from human platelets (n = 4, donors) and megakariocytes (MEG-01, n = 3 replicates).
ORGANISM(S): Homo sapiens (Human) 
2020-05-01 | PXD017976 | Pride
Innate immunity Inflammasomes Megakariocytes Platelets 
TranscriptomicsNanoString- Transcriptional profiling of LPS-primed and inflammasome-activated untouched, or platelet-depleted human CD14+ monocytes
The goal of this experiment was to explore how human platelets affect the transcriptional responses of primary human CD14+ blood monocytes to lipopolysaccharide (LPS), and NLRP3 activation with Nigericin. For this purpose, we analyzed the mRNA expression of 770 myeloid-specific transcripts using the...
ORGANISM(S): Homo sapiens 
2024-05-31 | E-MTAB-14072 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Profiling of Ly6G− IA/IE− CD45+ CD11b+ CD115+ Mouse Monocytes: Impact of In Vivo Platelet Depletion and LPS Challenge
To examine the role of platelets in mouse monocyte function, we administered anti-GPIba antibody to deplete platelets or IgG as a control to 48 mice. After 12 hours, mice were either exposed to LPS or PBS (as a sham control) for 3 hours. Peripheral blood mononuclear cells (PBMCs) were collected, and...
ORGANISM(S): Mus musculus 
2024-06-15 | E-MTAB-14126 | biostudies-arrayexpress
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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