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MetabolomicsHorizontal Transfer of Bacteriocin Biosynthesis Genes Requires Metabolic Adaptation To Improve Compound Production and Cellular Fitness

Biosynthetic gene clusters (BGCs) encoding the production of bacteriocins are widespread among bacterial isolates and are important genetic determinants of competitive fitness within a given habitat. Staphylococci produce a tremendous diversity of compounds, and the corresponding BGCs are frequen...

2022-11-09 | MTBLS5196 | MetaboLights
UnknownNew hairworm (Nematomorpha, Gordiida) species described from the Arizona Madrean Sky Islands.
Not available
S-EPMC5806596 | biostudies-literature
ProteomicsNeuropeptides in Lineus longissimus larvae
The goal of this project was to identify potential neuropeptides in extracts from larvae of the nemertean species Lineus longissimus.
ORGANISM(S): Lineus longissimus 
2022-02-16 | PXD023147 | Pride
Larva Neuropeptides Nemertea 
ProteomicsToll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants
Sepsis caused by Gram-positive bacterial pathogens is a major fatal disease but its molecular basis remains elusive. Toll-like receptor 2 (TLR2) has been implicated in the orchestration of inflammation and sepsis but its role appears to vary for different pathogen species and clones. Accordingly, St...
ORGANISM(S): Staphylococcus aureus 
2016-06-08 | PXD004283 | Pride
Phenol-soluble modulins Lipopeptide Culture supernatant Quantitative label-free proteomics Exoproteome Staphylococcus aureus 
ProteomicsPhotoferrotroph R. palustris TIE-1
The underlying adaptations required by anoxygenic phototrophs to oxidize Fe(II), a potential stressor, are not well constrained. We used quantitative proteomics to compare cells of the photoferrotroph Rhodopseudomonas palustris TIE-1 grown photoautotrophically with Fe(II) or H2, and photoheterotroph...
ORGANISM(S): Rhodopseudomonas palustris TIE-1 
2018-06-25 | PXD009629 | Pride
Anoxygenic photosynthesis Oxidation Iron Photoferrotroph 
GenomicsTranscription Dynamically Patterns the Meiotic Chromosome-Axis Interface
Meiotic chromosomes are highly compacted yet remain transcriptionally active. To understand how chromosome folding accommodates transcription, we investigated the assembly of the axial element, the proteinaceous structure that compacts meiotic chromosomes and promotes recombination and fertility. We...
ORGANISM(S): Saccharomyces cerevisiae SK1 
2015-08-07 | E-GEOD-70112 | biostudies-arrayexpress
UnknownRandomized phase III study comparing paclitaxel/cisplatin/gemcitabine and gemcitabine/cisplatin in patients with locally advanced or metastatic urothelial cancer without prior systemic therapy: EORTC Intergroup Study 30987.
Not available
S-EPMC3341152 | biostudies-literature
GenomicsSalt augments macrophage-driven host defense in the skin
Immune cells regulate a hypertonic microenvironment in the skin; however, possible functions of increased skin Na+ concentrations are unknown. We found that Na+ accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania (L.) major as a model...
ORGANISM(S): Mus musculus 
2015-02-26 | E-MTAB-3343 | biostudies-arrayexpress
TranscriptomicsNanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity
A number of key regulators of mouse embryonic stem (ES) cell identity, including the transcription factor Nanog, show strong expression fluctuations at the single cell level. The molecular basis for these fluctuations is unknown. Here we used a genetic complementation strategy to investigate express...
ORGANISM(S): Mus musculus 
2012-08-30 | E-GEOD-40335 | biostudies-arrayexpress
GenomicsSARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes [10x]
CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified non-synonymous mutations in MHC-I restricted CD8+ T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding...
EGAS00001005060 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
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