Fraser Paul E PE

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At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods.

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S-EPMC11252333 | biostudies-literature

LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers

KRAS-mutant lung cancers frequently have inactivating mutations in LKB1, which enhances tumor growth, metastasis, and immune evasion. This study shows that LKB1 suppresses JNK stress signaling, and its loss in KRAS-mutant cells leads to JNK hyperactivation and apoptotic rewiring, making them sensiti...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2025-03-06 | MSV000097246 | MassIVE

Transcription profiling of SH-SY5Y cells after treatment with soluble Abeta42_wt, Abeta42_G33A and Abeta40 for different timepoints

Although amyloid-beta42 (Abeta42) has long been implicated in the pathogenesis of Alzheimer disease (AD), the biological basis of its effects remains uncertain. Intraneuronal Abeta accumulation in brains of patients with AD or Down syndrome, in animal models, and in cultured cells has suggested an e...

ORGANISM(S): Homo sapiens

2014-12-01 | E-MTAB-1841 | biostudies-arrayexpress

Common variants associated with plasma triglycerides and risk for coronary artery disease.

Not available

S-EPMC3904346 | biostudies-literature

Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7.

Not available

S-EPMC8185188 | biostudies-literature

Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission.

Not available

S-EPMC8866425 | biostudies-literature

Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study.