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TranscriptomicsBlood gene expression profile of control and crystalline silica exposed rats
The present research aimed to investigate peripheral blood gene expression profiling as a minimally invasive surrogate approach to study silica-induced pulmonary toxicity. Rats were exposed to crystalline silica by inhalation (15 mg/m3, 6 hours/day, 5 days). Pulmonary damage and blood gene expressio...
ORGANISM(S): Rattus norvegicus 
2011-12-02 | E-GEOD-27023 | biostudies-arrayexpress
UnknownSupplementation with Sucrosomial® iron leads to favourable changes in the intestinal microbiome when compared to ferrous sulfate in mice.
Not available
S-EPMC8803775 | biostudies-literature
TranscriptomicsATAC-seq of HEK293T cell line
An enhancer of chr8 (chr8:579137-581436) was deleted using CRISPR and the effects of its deletion were assessed using ATAC-seq
ORGANISM(S): Homo sapiens 
2017-08-01 | E-MTAB-5702 | biostudies-arrayexpress
UnknownRandomized trial of bendamustine-rituximab or R-CHOP/R-CVP in first-line treatment of indolent NHL or MCL: the BRIGHT study.
Not available
S-EPMC4260975 | biostudies-literature
UnknownRobust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.
Not available
S-EPMC4931879 | biostudies-literature
UnknownIncreased susceptibility of cystic fibrosis airway epithelial cells to ferroptosis.
Not available
S-EPMC8670191 | biostudies-literature
TranscriptomicsTranscriptomics Analysis of Lungs and Peripheral Blood of Crystalline Silica Exposed Rats
Non-invasive or minimally invasive surrogate approaches to detect/predict target organ toxicity have significant practical applications in occupational toxicology. Presently, using a rat model, we have investigated the potential application of peripheral blood transcriptomics as a practical approach...
ORGANISM(S): Rattus norvegicus 
2012-12-31 | E-GEOD-36208 | biostudies-arrayexpress
UnknownResults from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse.
Not available
S-EPMC3069671 | biostudies-literature
TranscriptomicsMolecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats
Identification of molecular target(s) and mechanism(s) of silica-induced pulmonary toxicity is important for the intervention and/or prevention of diseases associated with occupational exposure to crystalline silica. Rats were exposed to crystalline silica by inhalation (15 mg/m3, 6 h/day, 5 days) a...
ORGANISM(S): Rattus norvegicus 
2012-06-29 | E-GEOD-32147 | biostudies-arrayexpress
TranscriptomicsPulmonary toxicity and global gene expression changes in response to sub-chronic inhalation exposure to crystalline silica in rats
Occupational exposure to crystalline silica results in serious health effects, most notably, silicosis and cancer. A proper understanding of the mechanism(s) underlying the initiation and progression of silica-induced pulmonary toxicity is critical for the intervention and/or prevention of the adver...
ORGANISM(S): Rattus norvegicus 
2014-07-01 | E-GEOD-49144 | biostudies-arrayexpress
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