Blood gene expression profile of control and crystalline silica exposed rats

ABSTRACT: The present research aimed to investigate peripheral blood gene expression profiling as a minimally invasive surrogate approach to study silica-induced pulmonary toxicity. Rats were exposed to crystalline silica by inhalation (15 mg/m3, 6 hours/day, 5 days). Pulmonary damage and blood gene expression profiles were determined at various latency periods (0 - 16 weeks). Silica exposure resulted in pulmonary toxicity and this was evidenced by histological changes in the lungs and elevation of LDH activity, and total protein and albumin contents in the bronchoalveolar lavage fluid (BALF) of the rats. Microarray analysis of global gene expression profiles in the blood of the rats identified genes that were differentially expressed in response to silica exposure and toxicity. The number of signif

ORGANISM(S): Rattus norvegicus

SUBMITTER: Rajendran Sellamuthu 

PROVIDER: E-GEOD-27023 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress